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ompounding a previously described Bmi1 (zeige BMI1 ELISA Kits)-transgene and Pten-deficiency prostate cancer mouse model with the Ezh2 (zeige EZH2 ELISA Kits) transgene did not enhance tumour progression or drive metastasis formation. In conclusion, we here report the generation of a wildtype Ezh2 (zeige EZH2 ELISA Kits) overexpression mouse model that allows for intravital surveillance of tissues with activated transgene
In conclusion, our data indicated that miR (zeige MLXIP ELISA Kits)-26a potentially contributes to the beta-cell dysfunction in T2DM, and miR (zeige MLXIP ELISA Kits)-26a may be a new therapeutic strategy against T2DM.
CFTR attaches tumor suppressor PTEN to the membrane and promotes anti Pseudomonas aeruginosa immunity.
These findings indicate that PTEN not only targets tumor cells themselves by impacting cell behaviors, but also blocks osteoclast-mediated bone destruction, leading to interruption of the vicious cycle during osteosarcomagenesis
further molecular mechanisms of HOTAIR action in cardiac hypertrophy (CH) demonstrated that HOTAIR may act as a competing endogenous RNA (ceRNA) for miR-19, thereby modulating the dis-inhibition of its endogenous target PTEN and playing an important role in inhibiting CH progress.
Setdb1 (zeige SETDB1 ELISA Kits) regulates PTEN/AKT (zeige AKT1 ELISA Kits)/FOXO1 (zeige FOXO1 ELISA Kits) pathway to inhibit Spermatogonial stem cells apoptosis.
Data indicate a functional circuit linking PTEN and LXRs, and highlights LXRs as metabolic gatekeepers that are able to constrain prostate cancer (PCa (zeige ENPP1 ELISA Kits)) progression.
phosphorylated-Pten promotes the proliferation and differentiation of hematopoietic stem cells.
Results indicate miR-130a as an oncogenic miRNA that targets PTEN to drive malignant cell survival and tumor growth.
PTEN loss and activation of K-RAS (zeige HRAS ELISA Kits) and beta-catenin (zeige CTNNB1 ELISA Kits) cooperate to accelerate prostate tumourigenesis.
The current results suggested that genetic variants at TEP1 SNPs rs1760893 and rs1713423 may be associated significantly with increased risk of stomach cancer.
TEP1 Polymorphisms are not associated with Hepatocellular Carcinoma in Thai Patients with Chronic Hepatitis B Virus Infection.
These data suggest that genetic variations in the TEP1 gene may be biomarkers for risk of PCa (zeige FLVCR1 ELISA Kits) and BCR (zeige BCR ELISA Kits) after RP.
8 common SNPs in telomerase reverse transcriptase (TERT (zeige TERT ELISA Kits)) and telomerase-associated protein 1 (TEP1) were genotyped.
the protein levels of MVP (zeige MVP ELISA Kits), TEP1 and vPARP (zeige PARP4 ELISA Kits) are actually increased in the highergrade tumors suggesting existence of post-transcriptional regulation of vault component production.
TP1 (zeige RPLP2 ELISA Kits) expression did not change after cisplatin exposure for 72 hours.
TEP1, hTR (zeige F2R ELISA Kits), hsp90 (zeige HSP90 ELISA Kits), p23, and dyskerin (zeige DKC1 ELISA Kits) remained at high and unchanged levels throughout up- or down regulation of telomerase activity.
TEP1, TOPOIIalpha, and HSP90 (zeige HSP90 ELISA Kits) interact directly with BLM in vitro and modulate its helicase activity on telomere-like DNA substrates but not on non-telomeric substrates.
This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans.
mutated in multiple advanced cancers 1
, phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
, protein tyrosine phosphatase and tensin-like protein
, phosphatase and tensin homolog deleted on chromosome ten
, telomerase protein component 1
, telomerase protein 1
, p80 telomerase homolog
, telomerase-associated protein 1
, p80 homolog
, TROVE domain family, member 1