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Human IGF2 ELISA Kit für Competition ELISA - ABIN414722
Baykus, Gurates, Aydin, Celik, Kavak, Aksoy, Sahin, Deniz, Gungor, Guzel, Minareci: Changes in serum obestatin, preptin and ghrelins in patients with Gestational Diabetes Mellitus. in Clinical biochemistry 2012
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Human IGF2 ELISA Kit für Sandwich ELISA - ABIN365303
Yao, Yao, Wang, Dong, Wu, Qiu, Yan, Yu, Chen, Sai, Zhang, Yang: Inhibition of autocrine IGF-II on effect of human HepG2 cell proliferation and angiogenesis factor expression. in Tumour biology 2012
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Mouse (Murine) IGF2 ELISA Kit für Sandwich ELISA - ABIN625133
Dobie, Ahmed, Staines, Pass, Jasim, MacRae, Farquharson: Increased linear bone growth by GH in the absence of SOCS2 is independent of IGF-1. in Journal of cellular physiology 2015
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Study shows impact of folic acid intake during pregnancy on genomic imprinting of IGF2/H19 (zeige NCKAP1 ELISA Kits) and 1-carbon metabolism
These findings suggest that reducing IGF2 isoform 2 expression in relevant tissues has potential as a new therapeutic strategy for type 2 diabetes, even beyond the Latin American population, with no major adverse effects on health or reproduction.
These data suggest the involvement of IGF-2, IGF-1R, IGF-2R and PTEN in temporo-spatial patterning of basic cellular processes (proliferation, differentiation) during normal tooth development.
IGF2 also requires integrin binding for signaling functions, and the IGF2 mutants that cannot bind to integrins act as antagonists of IGF1R (zeige IGF1R ELISA Kits).
this is the first report of IGF2/H19 (zeige NCKAP1 ELISA Kits) domain triplication associated with BWS (zeige CDKN1C ELISA Kits) or SRS (zeige SMS ELISA Kits) and the second report of a maternal amplification of this region in a patient with clinical features of SRS (zeige SMS ELISA Kits). This study further supports the hypotheses that the amplification of the H19 (zeige NCKAP1 ELISA Kits)/IGF2 region on the maternal chromosome can lead to an SRS (zeige SMS ELISA Kits) phenotype.
stroma-induced IGF2 promotes colon cancer progression in a paracrine and autocrine manner and propose IGF2 as potential target for tumor stroma cotargeting strategies.
We identified vascular INSR (zeige INSR ELISA Kits) expression as a potential biomarker for progression in bladder cancer. The data suggest that IGF-2/INSR (zeige INSR ELISA Kits) mediated paracrine crosstalk between bladder cancer cells and endothelial cells is functionally involved in tumour angiogenesis and may thus represent a new therapeutic target.
Insulin (zeige INS ELISA Kits)-Like Growth Factor System in Articular Cartilage
Methylation of IGF2AS is altered 20 years after preterm birth at VLBW. Altered methylation may be a mechanism of later increased disease risk but more data are needed to indicate causality
Prenatal 'unhealthy diet' was positively associated with IGF2 methylation at birth, and with ADHD and conduct disorder.
Igf2 regulates early neural and cardiovascular development in zebrafish embryos.
The IGF2 expression has also been reported at earlier stages in fish.
zebrafish orthologs of IGF2 function in dorsal midline development during segmentation/neurulation, whereas one paralog, igf2b, has evolved additional, distinct functions during subsequent organogenesis.
Epithelial IGF1R is dispensable for IGF2-mediated enhanced intestinal adaptation after small bowel resection in retinoblastoma-deficient mice.
These findings indicate that IGF-II reduces PGC-1alpha (zeige PPARGC1A ELISA Kits) expression in skeletal muscle cells through a mechanism involving PI3K-Akt (zeige AKT1 ELISA Kits)-FoxO1 (zeige FOXO1 ELISA Kits) but not p38 MAPK (zeige MAPK14 ELISA Kits) or Erk1/2 (zeige MAPK1/3 ELISA Kits) MAPK (zeige MAPK1 ELISA Kits) pathways.
Here the authors show that fibroblast growth factor 22 (FGF22 (zeige FGF22 ELISA Kits)), a target-derived presynaptic organizer in the mouse hippocampus, induces the expression of insulin-like growth factor 2 (IGF2) for the stabilization of presynaptic terminals.
Loss of Igf2 Gene Imprinting is associated with Prostate Cancer.
IGF2 controls bone growth by regulating glucose metabolism in chondrocytes.
These results demonstrate that overexpressed IGF-2 is the major tumorigenic driver in a subset of CRCs and encourage testing of MEDI-573, alone and in combinations, in IGF2-overexpressing CRC (zeige SCRIB ELISA Kits) patients.
results demonstrate that the H19 (zeige NCKAP1 ELISA Kits)-Igf2 axis is negatively regulated by CTCF (zeige CTCF ELISA Kits)-PHB1 (zeige PHB ELISA Kits) cooperation and that H19 (zeige NCKAP1 ELISA Kits) is involved in modulating the growth-suppressive effect of PHB1 (zeige PHB ELISA Kits) in the liver.
Our study reveals that the expression level of Igf2 is critical to maintain the balance between stem cell self-renewal and differentiation, presumably by regulating the interaction between HSC (zeige FUT1 ELISA Kits) and their niche.
To test the tumorigenic potential of different cell types in the developing kidney, we used kidney progenitor-specific Cre recombinase alleles to introduce Wt1 and Ctnnb1 mutations, two alterations observed in Wilms tumor, into embryonic mouse kidney, with and without biallelic Igf2 expression, another alteration that is observed in a majority of tumors
This study demonstrated that the Decreased IDE and IGF2 expression in the cerebral cortex of pups by early life lead exposure.
trans-associations occur between three imprinted genes IGF2, DLK1 and MEG3 both in fetal liver and muscle cells.
A single nucleotide polymorphism in a regulatory region of intron 3 within the porcine IGF2 gene is associated with increased lean deposition and decreased fat deposition in pigs with paternal A alleles compared with pigs with paternal G alleles.
These findings indicated that the mRNA of H19 (zeige NCKAP1 ELISA Kits) and IGF2 genes is susceptible to in vitro environments during the process of ES cell derivation from blastocysts but DNA methylation (zeige HELLS ELISA Kits) status at this region was well maintained.
study did not find any significant associations for polymorphisms in insulin (zeige INS ELISA Kits)-like grwoth factor 2, GTP Binding Protein (zeige RND1 ELISA Kits) alpha Subunits, Gs and melanocortin receptor 4 (zeige MC4R ELISA Kits) genes with reproductive traits of Polish Landrace and Large White pigs
The results suggested that IFG (zeige IFNG ELISA Kits)-1 and -2 and their receptors are differentially expressed at the maternal and fetal components of the attachment site.
Genetic variation in the promoter region of the IGF2 gene is associated with intramuscular fat content in porcine skeletal muscle.
The IGF2 G allele has strong adipogenic effects at the subcutaneous adipose tissue level and enhances the intermuscular fat content in ham (zeige ATF7IP ELISA Kits).
IGF-I (zeige IGF1 ELISA Kits), IGF-II, and IGFBP-3 (zeige IGFBP3 ELISA Kits) mRNA were positively correlated with IGF-IR from 50E to 180D, suggesting that the expression of IGF-system genes exhibits specific developmental patterns in the skeletal muscle tissues.
The imprinting status in adult liver, muscle and kidney tissues were also not reflected in the methylation patterns of IGF2 DMRs 1 and 2.
The expression of IGF-I and IGF-II in native growth plates of prepubertal piglets and under different cell culture conditions, was compared.
Methylation pattern in a CpG island of the IGF2 gene in cumulus cells from 1-3 mm and >/= 8.0 mm follicles and the effects of in vitro maturation on this pattern.
Our results provide evidence that polymorphisms in the IGF2 gene are associated with growth traits, and may be used for marker-assisted selection in beef cattle breeding program
The identification of the polymorphisms in the IGF2 gene that were significantly associated with growth traits in cattle.
Polymorphisms in the IGF2 gene are associated with cattle growth traits.
The LEP (zeige LEP ELISA Kits), IGF2 and CCL2 (zeige CCL2 ELISA Kits) genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.
Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation (zeige HELLS ELISA Kits) patterns of the IGF2 and IGF2R (zeige IGF2R ELISA Kits) genes, although individual variation in their methylation patterns among bulls was observed.
The reduction in IGFs mRNA level after 5 days of life in the duodenum (IGF-1 (zeige IGF1 ELISA Kits) and IGF-2) and in the jejunum (IGF-1 (zeige IGF1 ELISA Kits)) was associated with reduction in villi length (duodenum and jejunum) and the increase of crypt depth (duodenum).
Changes in the methylation pattern of IGF2 during in vitro maturation were different between incompetent and competent oocytes, and this characteristic may be useful as a molecular marker in studies of oocyte competence in cattle.
Data describes the long-term changes to skeletal muscle growth and IGF1 (zeige IGF1 ELISA Kits), 2, 1R, and 2R mRNA expression in progeny after exposure to high and low levels of maternal nutrient intake during the first two trimesters of gestation in the bovine.
findings support work which suggests that the insulin-like growth factor 2 locus is an important biological regulator of milk production in dairy cattle
increased endogenous IGF1 (zeige IGF1 ELISA Kits) and IGF2 expression by the blastocyst compensates for the loss of systemic insulin (zeige INS ELISA Kits) and IGF.
Data suggest that metabolism of IGF1 (zeige IGF1 ELISA Kits), IGF2, and IGFBP3 (insulin-like growth factor binding protein-3 (zeige IGFBP3 ELISA Kits)) can be altered by dietary modifications (here, long-term caloric restriction in Welsh Pony mares).
Methylation of three selected CpG islands of promoter of equine IGF2 gene was comparable between young and old horses, suggesting that aging could not be considered as a factor modulating methylation status of selected CpG islands within equine IGF2 gene.
This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
insulin-like growth factor II
, insulin-like growth factor type 2
, insulin-like growth factor 2
, insulin-like growth factor 2b
, insulin-like growth factor 2-A
, insulin-like growth factor II-A
, multiplication-stimulating polypeptide
, Insulin-like growth factor II (somatomedin A)
, insulin-like growth factor II (IGF-II)
, insulin-like growth factor II isoform 2 variant 4 preprotein
, multiplication-stimulating activity
, insulin growth factor 2
, insulin-like growth factor-II
, prepro-insulin-like growth factor-II
, Insulin-like growth factor 2-B
, insulin-like growth factor 2 (somatomedin A)
, insulin-like growth factor 2-B
, insulin-like growth factor II-B
, Insulin-like growth factor II-B