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High TEC (zeige NR4A3 ELISA Kits) expression is associated with the development of Mallory Denk Bodies in balloon cells in alcoholic hepatitis.
using RNA interference, the identified compounds corroborate the role of Tec (zeige NR4A3 ELISA Kits) kinase in unconventional secretion of FGF2 (zeige FGF2 ELISA Kits).
These results provide the first evidence that Nef interacts with cytoplasmic tyrosine kinases of the Tec (zeige NR4A3 ELISA Kits) family and suggest that Nef provides a mechanistic link between HIV-1 and Itk (zeige ITK ELISA Kits) signaling in the viral life cycle.
results suggest that the oncogenic effect of the t(3;9) translocation may be due to the TFG-TEC (zeige NR4A3 ELISA Kits) chimeric protein and that fusion of the TFG (NTD) to the TEC (zeige NR4A3 ELISA Kits) protein produces a gain-of-function chimeric product
Overexpression of Tec (zeige NR4A3 ELISA Kits) is associated with the tumorigenesis and development of liver cancer.
Tec (zeige NR4A3 ELISA Kits) kinase has a crucial role in regulating FGF2 (zeige FGF2 ELISA Kits) secretion under various physiological conditions
inhibits CD25 (zeige IL2RA ELISA Kits) expression in human T-lymphocytes
Chemotactic factor-induced recruitment and activation of Tec (zeige NR4A3 ELISA Kits) family kinases in human neutrophils
The AF2 domain of the orphan nuclear receptor (zeige ESRRB ELISA Kits) is essential for the transcriptional activity of the oncogenic fusion protein EWS (zeige EWSR1 ELISA Kits)
specificity in tyrosine phosphorylation of SH3 domains in vitro is high and, therefore, SH3 domain (zeige ITSN1 ELISA Kits) phosphorylation is required for a distinct function in signaling
these data indicate that in mature B cells, Tec (zeige NR4A3 ELISA Kits) and Btk (zeige BTK ELISA Kits) may compete for activation of the Akt (zeige AKT1 ELISA Kits) signaling pathway, whereby the activating capacity of Btk (zeige BTK ELISA Kits) is limited by the presence of Tec (zeige NR4A3 ELISA Kits) kinase.
Tec (zeige NR4A3 ELISA Kits) enhances c-Maf (zeige MAF ELISA Kits)-dependent IL-4 (zeige IL4 ELISA Kits) promoter activity. This effect of Tec (zeige NR4A3 ELISA Kits) is counteracted by Ptpn22 (zeige PTPN22 ELISA Kits), which physically interacts with and facilitates tyrosine dephosphorylation of c-Maf (zeige MAF ELISA Kits) thereby attenuating its transcriptional activity.
identify dectin-1 (zeige CLEC7A ELISA Kits) as the pathogen recognition receptor being required for Syk (zeige SYK ELISA Kits)-dependent Tec (zeige NR4A3 ELISA Kits) activation.
Btk (zeige BTK ELISA Kits), Tec (zeige NR4A3 ELISA Kits), Bmx (zeige BMX ELISA Kits) are required for TLR-dependent signaling in many types of myeloid cells while being tissue-specific.
Tec (zeige NR4A3 ELISA Kits) kinase can act as a prosurvival factor and is regulated by IGF-I (zeige IGF1 ELISA Kits) in human neutrophils through PI(3 (zeige PI3 ELISA Kits))K activation.
TEC (zeige NR4A3 ELISA Kits) promotes hepatocyte proliferation and regeneration and is involved in Hepatocyte Growth Factor (zeige HGF ELISA Kits)-induced Erk (zeige EPHB2 ELISA Kits) signaling pathway.
our data indicated a critical role for Tec (zeige NR4A3 ELISA Kits) in T cell-intrinsic signaling pathways that regulate the in vivo generation of CD44 (zeige CD44 ELISA Kits)(high)CD62L (zeige SELL ELISA Kits)(-) effector/memory Th17 populations.
These experiments expand the role of the Tec (zeige NR4A3 ELISA Kits) family in the heart, identifying the Tec (zeige NR4A3 ELISA Kits) isoform as an ischemic injury-induced isoform
the absence of the Tec (zeige NR4A3 ELISA Kits) family kinase Itk (zeige ITK ELISA Kits), which regulates the production of Th2 cytokines, leads to resistance in the C57BL/6 background, but decreases susceptibility on the BALB/c background
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.
, tyrosine-protein kinase Tec
, Tec protein tyrosine kinase
, transient erythroblastopenia of childhood
, tec protein tyrosine kinase
, Tyrosine-protein kinase Tec
, tyrosine-protein kinase Tec-like
, cytoplasmic tyrosine kinase, Dscr28C related