XRCC4 Proteine (XRCC4)

Bezeichnung:
X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 Proteine (XRCC4)
Auf www.antikoerper-online.de finden Sie aktuell 6 X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen XRCC4 Antikörper (108) und XRCC4 Kits (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 126 XRCC4 Produkte verfügbar.
Synonyme:
2310057B22Rik, AW413319, AW545101, homolog of human DNA ligase iv-binding protein XRCC4, MGC81443, zgc:73312
alle Proteine anzeigen Gen GeneID UniProt
XRCC4 7518 Q13426
Maus XRCC4 XRCC4 108138 Q924T3
Ratte XRCC4 XRCC4 309995  

Weitere Synonyme anzeigen

XRCC4 Proteine (XRCC4) nach Spezies

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Am meisten referenzierte XRCC4 Proteine

  1. Human XRCC4 Protein expressed in HEK-293 Cells - ABIN2735698 : Myers, Maxwell, Wang: Quantification of XRCC and DNA-PK proteins in cancer cell lines and human tumors by LC-MS/MS. in Bioanalysis 2014 (PubMed)

Weitere Proteine zu XRCC4 Interaktionspartnern

Arabidopsis thaliana X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) Interaktionspartner

  1. XRCC4 has a negative role in Agrobacterium T-DNA integration.

Human X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) Interaktionspartner

  1. the various XRCC4 mutations that lead to primordial dwarfism and their impact on non-homologous end joining and V(D)J recombination are discussed (Review)

  2. XRCC4 expression might have an influence on results of radiotherapy for patients with esophageal squamous cell carcinoma.

  3. uterine cervical cancer patients with high Ku86 (zeige XRCC5 Proteine) and XRCC4 expression had a significantly lower 5-year metastasis-free rate than others.

  4. Frequencies of XRCC4-1394 T/G+G/G genotypes were higher in patients (%34) than the controls (%18.7). The statistical analysis revealed that the individuals who had XRCC4-1394 T/G+G/G genotype had an increased risk for autism spectrum disorder (OR = 2.23, 95% CI = 1.10-4.55)

  5. Genetic Variations in XRCC4 (rs1805377) is not Associated with Hepatocellular Carcinoma in Thai Patients with Hepatitis B Virus Infection.

  6. These results suggested potential usefulness of the phosphorylation status of XRCC4 Ser320 as an indicator of DNA-PK functionality in living cells.

  7. Association between insertion/deletion polymorphism in intron 3 of XRCC4 and susceptibility to type I bipolar disorder

  8. For XRCC4 (rs1805377) polymorphism, no difference was found in distribution between the ESCC and control groups.

  9. using dual- and quadruple-trap optical tweezers combined with fluorescence microscopy, we show how human XRCC4, XLF (zeige NHEJ1 Proteine) and XRCC4-XLF (zeige NHEJ1 Proteine) complexes interact with DNA in real time

  10. The ends are then closely aligned, which requires XLF (zeige NHEJ1 Proteine), a non-catalytic function of XRCC4-LIG4 (zeige LIG4 Proteine), and DNA-PK activity

Mouse (Murine) X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4) Interaktionspartner

  1. We find that non-canonical HR termination can occur in the absence of the classical non-homologous end joining gene XRCC4. We observe obligatory use of microhomology (MH)-mediated end joining and/or nucleotide addition during rejoining with the second end of the break

  2. Data show that combined deletion of X-ray repair cross-complementing protein 4 (Xrcc4) and tumor suppressor p53 (Trp53 (zeige TP53 Proteine)) predisposes B cells to lymphomagenesis.

  3. FBXW7 (zeige FBXW7 Proteine) facilitates nonhomologous end-joining via K63-linked polyubiquitylation of XRCC4 in tumor cells.

  4. The present results collectively indicated that Lys271, but not Lys210, of XRCC4 is required for the nuclear localization of XRCC4 and LIG4 (zeige LIG4 Proteine) and that the nuclear localizing ability is essential for DSB repair function of XRCC4.

  5. DNA-PK and ATM (zeige ATM Proteine) acts in parallel upstream of XRCC4, regulating through phosphorylation

  6. XRCC4 C-terminal point mutants, R325F and N326L, are functionally deficient in terms of cell survival after irradiation.

  7. These results establish that nonrecurrent CNVs can be, and frequently are, formed by mechanisms other than Xrcc4-dependent NHEJ.

  8. analysis of the association of radiation-induced XRCC4 with chromatin DNA, by biochemical fractionation

  9. conditional inactivation of the XRCC4 in nestin (zeige NES Proteine)-expressing neuronal progenitor cells, although leading to no obvious phenotype in a WT background, leads to early onset of neuronally differentiated medulloblastomas (MBs (zeige NEU2 Proteine)) in a p53 (zeige TP53 Proteine)-deficient background

  10. DNA-PK kinase activity results in disassembly of the Ku/DNA ligase IV (zeige LIG4 Proteine)/Xrcc4 complex

XRCC4 Protein Überblick

Protein Überblick

The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants.

Alternative names and synonyms associated with XRCC4

  • X-ray repair complementing defective repair in Chinese hamster cells 4 (XRCC4)
  • X-ray repair complementing defective repair in Chinese hamster cells 4 (xrcc4)
  • DNA repair protein XRCC4-like protein (XRCC4)
  • X-ray repair complementing defective repair in Chinese hamster cells 4 (Xrcc4)
  • 2310057B22Rik Protein
  • AW413319 Protein
  • AW545101 Protein
  • homolog of human DNA ligase iv-binding protein XRCC4 Protein
  • MGC81443 Protein
  • zgc:73312 Protein

Bezeichner auf Proteinebene für XRCC4

DNA repair protein XRCC4 , X-ray repair complementing defective repair in Chinese hamster cells 4 , DNA-repair protein XRCC4 , X-ray repair cross complementing protein 4 , X-ray repair cross-complementing protein 4 , X-ray repair, complementing defective, repair in Chinese hamster

GENE ID SPEZIES
488923 Canis lupus familiaris
393759 Danio rerio
427325 Gallus gallus
443786 Xenopus laevis
471491 Pan troglodytes
100127743 Xenopus (Silurana) tropicalis
100173078 Pongo abelii
100603402 Nomascus leucogenys
821885 Arabidopsis thaliana
7518 Homo sapiens
613590 Bos taurus
108138 Mus musculus
309995 Rattus norvegicus
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