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Rad51 (zeige RAD51 ELISA Kits) and Rad52 physically interact with CENP-ACaCse4 in vivo.
Rad52 prevents chromosome loss and truncation.
Rad52 inverse strand exchange plays an important role in RNA-templated double strand break repair in vivo.
The mitotic DNA synthesis is RAD52 dependent, and RAD52 is required for the timely recruitment of MUS81 (zeige MUS81 ELISA Kits) and POLD3 (zeige POLD3 ELISA Kits) to common fragile sites in early mitosis.
Human RAD52-null cells retain a significant level of single-strand annealing (SSA (zeige TRIM21 ELISA Kits)) activity demonstrating perforce that additional SSA (zeige TRIM21 ELISA Kits)-like activities must exist in human cells. Moreover, the SSA (zeige TRIM21 ELISA Kits) activity associated with RAD52 is involved in, but not absolutely required for, most homology-directed repair (HDR (zeige GATA3 ELISA Kits)) subpathways. Specifically, a deficiency in RAD52 impaired the repair of DNA DSBs.
Data suggest RAD52 binds tightly to RPA (zeige RPA1 ELISA Kits)/ssDNA complex in presynaptic complex and inhibits RPA (zeige RPA1 ELISA Kits) turnover; during presynaptic complex assembly, most of RPA (zeige RPA1 ELISA Kits) and RAD52 is displaced from ssDNA, but some RAD52/RPA (zeige RPA1 ELISA Kits)/ssDNA complexes persist as interspersed clusters surrounded by RAD51 (zeige RAD51 ELISA Kits) filaments. (RAD52 = Rad52 DNA repair/recombination protein (zeige RAD50 ELISA Kits); RPA (zeige RPA1 ELISA Kits) = replication protein A; ssDNA = single-stranded DNA; RAD51 (zeige RAD51 ELISA Kits) = Rad51 (zeige RAD51 ELISA Kits) recombinase (zeige RAG1 ELISA Kits))
The C-terminal region of yRad52, but not of hRAD52, is involved in ssDNA annealing. This suggests that the second DNA binding site is required for the efficient ssDNA annealing by yRad52. We propose an updated model of Rad52-mediated ssDNA annealing.
Study discovered two cis (zeige CISH ELISA Kits)-expression quantitative trait loci SNPs in the RAD52 gene that are associated with its expression and are also associated with lung squamous cell carcinomas (LUSC) risk.
BRG1 (zeige SMARCA4 ELISA Kits)-RAD52 complex mediates the replacement of RPA (zeige RPA1 ELISA Kits) with RAD51 (zeige RAD51 ELISA Kits) on single-stranded DNA (ssDNA) to initiate DNA strand invasion. Loss of BRG1 (zeige SMARCA4 ELISA Kits) results in a failure of RAD51 (zeige RAD51 ELISA Kits) loading onto ssDNA, abnormal homologous recombination repair
these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of upper aerodigestive tract and lung squamous cell carcinoma tumors.
RAD52 rs7963551 single nucleotide polymorphism was significantly associated with glioma risk.
This study found that only the RAD52 rs7963551 single nucleotide polymorphism was significantly associated with hepatitis B virus related - hepatocellular carcinoma risk.
In cancer-prone, heterozygous APC (zeige APC ELISA Kits) mutant mice, homozygous deletion of the Rad52 gene suppressed tumor growth and prolonged lifespan.
Rad54 (zeige RAD54L ELISA Kits) has a key function in maintaining genomic integrity of the developing germ cells.
Loss of Rad52 partially rescues tumorigenesis and T-cell maturation in Atm (zeige ATM ELISA Kits)-deficient mice.
RAD52 modulates the outcome of recombinant HIV-l vector infection by markedly reducing the efficiency of productive integration events
Inactivation of RAD52 aggravates X-ray and mitomycine C sensitivity in mice with RAD54 (zeige RAD54L ELISA Kits) gene degect.
Cells expressing Rad52 splice variants favor sister chromatid repair.
Results indicate that RAD52 cooperates with OGG1 (zeige OGG1 ELISA Kits) to repair oxidative DNA damage and enhances the cellular resistance to oxidative stress.
The complete cDNA sequences of the pig RAD51 (zeige RAD51 ELISA Kits), RAD52, and RAD54 (zeige RAD54L ELISA Kits) genes, which are closely related to homologous recombination events, arae identified using molecular cloning technique in pigs.
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair.
RAD52 homolog (S. cerevisiae)
, DNA repair protein RAD52 homolog
, DNA repair protein RAD52 homolog-like
, RAD52 homolog
, potential dsDNA break repair annealing factor
, DNA repair and recombination protein, putative
, RAD52 protein
, recombination protein RAD52
, rhabdomyosarcoma antigen MU-RMS-40.23
, DNA repair protein RAD52
, RAD52 homolog isoform alpha