Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Proteine (POLD1)

Bezeichnung:
Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Proteine (POLD1)
Auf www.antikoerper-online.de finden Sie aktuell 4 Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Antikörper (49) und Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Kits (1) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 59 Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa Produkte verfügbar.
Synonyme:
125kDa, 5949, CAA61369, CDC2, CG5949, CRCS10, Dmel\\CG5949, Dm Poldelta, dnapol delta, DNA Pol Delta, l(3)72Ac, POLD, POLD3, Poldelta, Pol delta
alle Proteine anzeigen Gen GeneID UniProt
POLD1 5424 P28340
POLD1 18971 P52431
Ratte POLD1 POLD1 59294 O54747

Weitere Synonyme anzeigen

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Fruit Fly (Drosophila melanogaster) Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Interaktionspartner

  1. in Drosophila the alternative TRF1/BRF complex appears responsible for the initiation of all known classes of Pol III transcription

Human Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Interaktionspartner

  1. Our work highlights that mutations in different POLD1 domains can lead to phenotypic variability, ranging from dominantly inherited cancer predisposition syndromes, to mild MDPL phenotypes

  2. Germline or somatic variants in the POLE/POLD1 were identified in unresolved suspected Lynch syndrome cancers with mismatch repair defect.

  3. WRN or the Bloom syndrome helicase (BLM) stimulates DNA polymerase delta progression across telomeric G-rich repeats, only WRN promotes sequential strand displacement synthesis and FEN1 (zeige FEN1 Proteine) cleavage.

  4. study of complete exonuclease (zeige EXO1 Proteine) domains of POLE and POLD1 in 529 families characterized by presence of familial or early-onset mismatch repair proficient colorectal cancer, and/or APC (zeige APC Proteine)-negative and MUTYH (zeige MUTYH Proteine)-negative polyposis; results widen the phenotypic spectrum of the POLE/POLD1-associated syndrome and identify novel pathogenic variants

  5. POLD1 is a central mediator of DNA replication and repair, and it is implied in cancer and other pathologies. (Review)

  6. Inactivating POLD1 mutations are associated with colorectal cancer.

  7. Mutations in POLE and POLD1 in south east Asia women with grade 3 endometrioid endometrial carcinomas are associated with improved recurrence free survival.

  8. POLD1 germline mutations can result in a variably expressed and probably underdiagnosed segmental progeroid syndrome.

  9. None of the 1188 patients carried the POLD1 p.(Ser478Asn) variant. POLE germline variant carriers are also associated with a microsatellite instable colorectal cancer

  10. POLD1 plays important role in the regulation of cell cycle progression and DNA damage repair

Mouse (Murine) Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Interaktionspartner

  1. reducing expression of individual PRMT7 (zeige PRMT7 Proteine) target DNA repair genes showed that only the catalytic subunit of DNA polymerase (zeige POLB Proteine), POLD1, was able to resensitize PRMT7 (zeige PRMT7 Proteine) knock-down cells to DNA-damaging agents.

  2. A point mutation (D400A) in the proofreading domain of DNA polymerase delta, encoded by the Pold1 gene, inactivates the 3' --> 5' exonuclease (zeige EXOSC10 Proteine) of poldelta and causes a mutator and epithelial cancer phenotype in a recessive manner.

  3. Heterozygous mutation at L604 in the polymerase active site of DNA polymerase delta reduces life span, increases genomic instability, and accelerates tumorigenesis in an allele-specific manner, novel findings that have implications for human cancer.

  4. DNA polymerase delta is essential for mammalian early embryogenesis, and the 3'-5' exonuclease (zeige EXOSC10 Proteine) activity of DNA polymerase delta is dispensable for normal development but necessary to suppress tumorigenesis

Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1) Protein Überblick

Protein Überblick

This gene encodes the 125-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 6.

Alternative names and synonyms associated with Polymerase (DNA Directed), delta 1, Catalytic Subunit 125kDa (POLD1)

  • DNA-polymerase-delta (DNApol-delta)
  • DNA polymerase delta (POLD1)
  • polymerase (DNA-directed), delta 3, accessory subunit (POLD3)
  • polymerase (DNA-directed), delta 3, accessory subunit (pold3)
  • polymerase (DNA directed), delta 1, catalytic subunit (POLD1)
  • polymerase (DNA directed), delta 1, catalytic subunit (pold1)
  • polymerase (DNA directed), delta 1, catalytic subunit 125kDa (POLD1)
  • polymerase (DNA directed), delta 1, catalytic subunit (Pold1)
  • 125kDa Protein
  • 5949 Protein
  • CAA61369 Protein
  • CDC2 Protein
  • CG5949 Protein
  • CRCS10 Protein
  • Dmel\\CG5949 Protein
  • Dm Poldelta Protein
  • dnapol delta Protein
  • DNA Pol Delta Protein
  • l(3)72Ac Protein
  • POLD Protein
  • POLD3 Protein
  • Poldelta Protein
  • Pol delta Protein

Bezeichner auf Proteinebene für POLD1

CG5949-PA , DNA polymerase delta , DNA polymerase-delta , DNApol-delta-PA , lethal (3) 72Ac , DNA polymerase delta catalytic subunit , DNA-dependent DNA polymerase , DNA polymerase delta subunit 3 , polymerase (DNA directed), delta 3 , polymerase (DNA-directed), delta 3, accessory subunit , DNA-directed DNA polymerase delta 3 , DNA polymerase subunit delta 3 , polymerase (DNA directed), delta 1, catalytic subunit 125kDa , DNA-directed DNA polymerase delta 1 , DNA polymerase delta catalytic subunit-like , CDC2 homolog , DNA polymerase subunit delta p125 , DNA polymerase delta 1, catalytic domain , DNA polymerase delta, catalytic subunit

GENE ID SPEZIES
39746 Drosophila melanogaster
548092 Glycine max
419053 Gallus gallus
451422 Pan troglodytes
476806 Canis lupus familiaris
549310 Xenopus (Silurana) tropicalis
693601 Macaca mulatta
100051966 Equus caballus
456228 Pan troglodytes
610047 Canis lupus familiaris
719262 Macaca mulatta
734063 Xenopus (Silurana) tropicalis
100052455 Equus caballus
100389890 Callithrix jacchus
100456571 Pongo abelii
100525752 Sus scrofa
5424 Homo sapiens
18971 Mus musculus
59294 Rattus norvegicus
281990 Bos taurus
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