PNKP Proteine (PNKP)

Bezeichnung:
Polynucleotide Kinase 3'-Phosphatase Proteine (PNKP)
Auf www.antikoerper-online.de finden Sie aktuell 9 Polynucleotide Kinase 3'-Phosphatase (PNKP) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PNKP Antikörper (56) und PNKP Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 73 PNKP Produkte verfügbar.
Synonyme:
21.m03011, 1810009G08Rik, C21orf97, C21orf124, EIEE10, MCSZ, PKH, PNK, Tb06.28P18.320
alle Proteine anzeigen Gen GeneID UniProt
PNKP 59047  
PNKP 11284 Q96T60
Ratte PNKP PNKP 308576  

Weitere Synonyme anzeigen

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Weitere Proteine zu PNKP Interaktionspartnern

Mouse (Murine) Polynucleotide Kinase 3'-Phosphatase (PNKP) Interaktionspartner

  1. The work indicates that the phosphatase domain of Pnkp binds 3'-phosphorylated single-stranded DNAs in a manner that is highly dependent on the presence of the 3'-phosphate.

  2. Directed postnatal neural inactivation of PNKP affected specific subpopulations including oligodendrocytes, indicating a broad requirement for genome maintenance, both during and after neurogenesis.

  3. Structure of dsDNA bound to PNK 5'-kinase domain reveals DNA bending facilitating recognition of DNA ends in the context of single-strand/double-strand breaks, suggesting close functional cooperation in between the kinase/phosphatase active sites.

Human Polynucleotide Kinase 3'-Phosphatase (PNKP) Interaktionspartner

  1. Mutations in TDP1 (zeige TDP1 Proteine) and APTX (zeige APTX Proteine) have been linked to Spinocerebellar ataxia (zeige USP14 Proteine) with axonal neuropathy (SCAN1 (zeige CANT1 Proteine)) and Ataxia (zeige USP14 Proteine)-ocular motor apraxia 1 (AOA1 (zeige APTX Proteine)), respectively, while mutations in PNKP are considered to be responsible for Microcephaly with seizures (MCSZ) and Ataxia (zeige USP14 Proteine)-ocular motor apraxia 4 (AOA4).

  2. the role for PNKP in maintaining brain function and how perturbation in its activity can account for the varied pathology of neurodegeneration or microcephaly present in microcephaly with seizures and ataxia (zeige USP14 Proteine) with oculomotor apraxia 4 respectively.

  3. In 11 Portuguese patients, PNKP mutations cause ataxia (zeige USP14 Proteine) with oculomotor apraxia type 4.

  4. Here we report that purified wild-type (WT) ATXN3 (zeige ATXN3 Proteine) stimulates, and by contrast the mutant form specifically inhibits, PNKP's 3' phosphatase activity in vitro. ATXN3 (zeige ATXN3 Proteine)-deficient cells also show decreased PNKP activity

  5. We now report that the mutant ATXN3 (zeige ATXN3 Proteine) protein interacts with and inactivates PNKP (polynucleotide kinase 3'-phosphatase), an essential DNA strand break repair enzyme

  6. We identified homozygous or compound-heterozygous PNKP mutations in eight of the nine Portuguese families we studied, suggesting that, in Portugal, mutations in PNKP are the most frequent cause of ataxia (zeige USP14 Proteine) with oculomotor apraxia.

  7. we show that modest inhibition of PNKP in a PTEN knockout background enhances cellular radiosensitivity, suggesting that such a "synthetic sickness" approach involving the combination of PNKP inhibition with radiotherapy

  8. Mutations in PNKP have previously been associated with a syndrome of microcephaly, seizures and developmental delay (MIM (zeige MTSS1 Proteine) 613402), and is now associated with a neurodegenerative disorder.

  9. the interaction between PNKP and XRCC1 (zeige XRCC1 Proteine) has roles in the retention of XRCC1 (zeige XRCC1 Proteine) at DNA damage sites and in DNA alkylation damage repair

  10. The data suggest that all four known mutations associated with microcephaly, seizures and developmental delay reduce the cellular stability and level of PNKP protein, with three mutations likely ablating cellular DNA 5'-kinase activity and all of the mutations greatly reducing cellular DNA 3'-phosphatase activity.

PNKP Protein Überblick

Protein Überblick

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Alternative names and synonyms associated with PNKP

  • polynucleotide kinase 3'-phosphatase (Tc00.1047053507017.50)
  • polynucleotide kinase 3'-phosphatase (Tc00.1047053505807.190)
  • polynucleotide kinase 3'-phosphatase (Tb927.6.1580)
  • polynucleotide kinase 3'-phosphatase (BBOV_IV000690)
  • polynucleotide kinase 3'-phosphatase (CC1G_05202)
  • polynucleotide kinase 3'-phosphatase (PGTG_20262)
  • polynucleotide kinase 3'-phosphatase (PGTG_18987)
  • polynucleotide kinase 3'-phosphatase (pnkp)
  • polynucleotide kinase 3'- phosphatase (Pnkp)
  • polynucleotide kinase 3'-phosphatase (PNKP)
  • polynucleotide kinase 3'-phosphatase (Pnkp)
  • pyridoxal (pyridoxine, vitamin B6) kinase (PDXK)
  • 21.m03011 Protein
  • 1810009G08Rik Protein
  • C21orf97 Protein
  • C21orf124 Protein
  • EIEE10 Protein
  • MCSZ Protein
  • PKH Protein
  • PNK Protein
  • Tb06.28P18.320 Protein

Bezeichner auf Proteinebene für PNKP

polynucleotide kinase 3'-phosphatase , DNA 5'-kinase/3'-phosphatase , bifunctional polynucleotide phosphatase/kinase , polynucleotide kinase-3'-phosphatase , Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP) , pyridoxal kinase , pyridoxamine kinase , pyridoxine kinase , vitamin B6 kinase

GENE ID SPEZIES
3544419 Trypanosoma cruzi strain CL Brener
3548557 Trypanosoma cruzi strain CL Brener
3657794 Trypanosoma brucei brucei strain 927/4 GUTat10.1
5477454 Babesia bovis T2Bo
6009998 Coprinopsis cinerea okayama7130
10527435 Puccinia graminis f. sp. tritici CRL 75-36-700-3
10542867 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100137702 Xenopus laevis
100145800 Xenopus (Silurana) tropicalis
59047 Mus musculus
11284 Homo sapiens
484373 Canis lupus familiaris
308576 Rattus norvegicus
747683 Pan troglodytes
8566 Homo sapiens
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