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Data show the structure of the Cdc45/Mcm2-7/Psf1 (zeige GINS1 ELISA Kits) GINS (CMG (zeige CASK ELISA Kits)) helicase (zeige DNA2 ELISA Kits) in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.
the foxn1 (zeige FOXN1 ELISA Kits)-mcm2 axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish
Sld5 (zeige GINS4 ELISA Kits) a component of GINS complex interacts with SIK1 (zeige SIK1 ELISA Kits) and recruits it to the sites of DNA replication at the onset of S phase.
MCM2 expression in serrated colonic polyps demonstrates aberrant cellular proliferation and changes in the colonic microenvironment may promote adenoma morphogenesis and predisposition to malignancy.
these findings suggest that lnc-FTX may act as a tumor suppressor in hepatocellular carcinoma (HCC (zeige FAM126A ELISA Kits)) through physically binding miR (zeige MLXIP ELISA Kits)-374a and MCM2. It may also be one of the reasons for HCC (zeige FAM126A ELISA Kits) gender disparity and may potentially contribute to HCC (zeige FAM126A ELISA Kits) treatment
Data suggest that interaction of Mcm10 (zeige MCM10 ELISA Kits) with Mcm2-7 multimer requires Mcm10 (zeige MCM10 ELISA Kits) domain that contains amino acids 530-655, which overlaps with domain required for stable retention of Mcm10 (zeige MCM10 ELISA Kits) on chromatin; Mcm10 (zeige MCM10 ELISA Kits) conserved domain (amino acids 200-482) is essential for DNA replication; both conserved domain and Mcm2-7-binding domain are required for full activity of Mcm10 (zeige MCM10 ELISA Kits).
MCM2-MCM6 (zeige MCM6 ELISA Kits) complex is required for CHK2 (zeige CHEK2 ELISA Kits) chromatin loading and its phosphorylation to DNA damage response in squamous cell carcinoma cells.
BD ProExtrade mark C assay containing MCM2 and TOP2A (zeige TOP2A ELISA Kits) antibodies showed strong specific nuclear staining that correlated with increased cervical dysplasia and lesion severity.
these data suggest that positive MCM2 and negative TIP30 (zeige HTATIP2 ELISA Kits) expression are closely correlated with the clinical, pathological and biological parameters, in addition to poor prognosis in patients with gallbladder cancer.
knockdown of MCM2 or MCM6 could significantly inhibit foci forming of MDC1 in TE-1 nuclei in response to bleomycin-induced DNA damage (p < 0.001). This study indicates the direct interaction between MDC1 and MCMs in TE-1 nuclei.
PTEN regulates DNA replication through MCM2 and loss of PTEN function leads to replication defects and genomic instability.
MCM2 expression is higher in ovarian and endometrial high-grade serous carcinomas (HGSC) than in ovarian or endometrial endometrioid carcinoma. Knockdown in ovarian HGSC cell line decreased cell proliferation.
Data show that MRE11 (zeige MRE11A ELISA Kits)- and RAD51-dependent fork repair leading to reloading of the GINS onto the MCM-CDC45 complex still engaged with the DNA could be sufficient to restore a functional CDC45-MCM-GINS (CMG (zeige CASK ELISA Kits)) helicase (zeige DNA2 ELISA Kits) complex.
Mcm2-7 associate with Cdc45 and GINS to form a relatively stable CMG (Cdc45-MCM-GINS) complex.
ATM (zeige ATM ELISA Kits) and ATR (zeige ATR ELISA Kits) phosphorylate the functionally critical replication protein Mcm2 during both DNA damage and replication checkpoint responses in Xenopus egg extracts
MCM2-7 is the replicative helicase (zeige DNA2 ELISA Kits), dispensable for chromatin loading and pre-replicative complex (pre-RC) assembly, but required for origin unwinding during DNA replication
MCM2 is dynamically expressed in both proliferative and differentiated stromal cells during mouse periimplantation uterus. expression of Mcm2 is induced by progesterone action in the mouse uterine stroma. siRNA-mediated silencing of MCM2 arrests the cell cycle at G1-S transition during stromal cell proliferation. downregulation of Mcm2 could also compromise stromal cell differentiation.
MCM2 deficiency reduces DNA replication initiation in gene-rich regions of the genome.
these data demonstrate that active MCM2-7 repression is a physiologically important mechanism for RS-induced cell cycle arrest and genome maintenance on an organismal level.
Hematopoietic cells originally express higher levels MCM 2 protein and undergo more frequent apoptosis following doxorubicin-induced DNA-damage in the presence of the FLV envelope protein gp70 (zeige EMB ELISA Kits).
Mcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.
Accumulation and dynamics of Mcm2 are described during oogenesis and the first embryonic cell cycle.
gp70 (zeige EMB ELISA Kits) enhances cellular DNA-damage-induced signaling in association with host-specific cellular proteins including acinus (zeige ACIN1 ELISA Kits) and MCM2 resulting in the activation of DNA-PK to phosphorylate P53 (zeige TP53 ELISA Kits).
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined.
, minichromosome maintenance 2
, DNA replication licensing factor mcm2
, MCM2 minichromosome maintenance deficient 2, mitotin
, minichromosome maintenance protein 2
, DNA replication licensing factor MCM2
, cell devision cycle-like 1
, cyclin-like 1
, minichromosome maintenance deficient 2 (mitotin)
, minichromosome maintenance protein 2 homolog
, nuclear protein BM28
, minichromosome maintenance deficient 2 mitotin
, minichromosome maintenance complex component 7
, mini chromosome maintenance deficient 2