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functional genetic variants of GTF2H4 confer susceptibility to lung cancer.
GTF2H4 variants may not be associated with susceptibility to aspirin-exacerbated respiratory disease and obstructive symptoms in asthmatics.
A single nucleotide polymorphism variant within the general transcription factor IIH, polypeptide 4 gene, GTF2H4, on chromosome 6p21.33 was significantly associated with MS
General transcription factor IIH protects promoters from PC4 (zeige IFRD1 Proteine)-mediated repression by relieving the topological constraint imposed by PC4 (zeige IFRD1 Proteine) through the ERCC3 (zeige ERCC3 Proteine) helicase activity rather than by reducing the repressive activity of PC4 (zeige IFRD1 Proteine) via its phosphorylation.
The second domain of TFIIH p62 (zeige GTF2H1 Proteine) subunit(residues 186-240) contains a region of high sequence conservation with an invariant tyrosine/phenylalanine motif which could play a key role as a protein-protein recognition module within TFIIH (zeige GTF2H1 Proteine).
TFIIH (zeige GTF2H1 Proteine) uses an expanded proximal promoter to regulate c-myc (zeige MYC Proteine) expression
We conclude that the recruitment and activation of TFIIH (zeige GTF2H1 Proteine) represents a rate-limiting step for the emergence of HIV from latency.
Alterations of chromatin at the RNA polymerase II stall site, which depend on CSB and TFIIH at least, are necessary for the UV-induced translocation of CSA to the nuclear matrix.
XPG (zeige ERCC5 Proteine) forms a stable complex with TFIIH (zeige GTF2H1 Proteine), which is active in transcription and nucleotide excision repair
mechanism in which the helicase activity of XPB (zeige GTF2H5 Proteine) is not used for the opening and repair of damaged DNA, which is instead only driven by its ATPase activity, in combination with the helicase activity of XPD (zeige ERCC2 Proteine)
Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II (By similarity).
general transcription factor IIH, polypeptide 4
, general transcription factor II H, polypeptide 4
, ATP-binding cassette, sub-family F (GCN20), member 1
, General transcription factor IIH polypeptide 4
, general transcription factor IIH subunit 4
, general transcription factor IIH, polypeptide 4, 52kDa, gene 2
, general transcription factor IIH, polypeptide 4, 52kDa
, general transcription factor IIH subunit 4-like
, TFIIH basal transcription factor complex p52 subunit
, basic transcription factor 2 52 kDa subunit
, TFIIH transcription/DNA repair factor p52 subunit
, BTF2 p52
, general transcription factor IIH polypeptide 4
, general transcription factor IIH, polypeptide 4, 52kDa, gene 1