Family with Sequence Similarity 175, Member A Proteine (FAM175A)

Bezeichnung:
Family with Sequence Similarity 175, Member A Proteine (FAM175A)
Auf www.antikoerper-online.de finden Sie aktuell 9 Family with Sequence Similarity 175, Member A (FAM175A) Proteine von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Family with Sequence Similarity 175, Member A Antikörper (54) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 70 Family with Sequence Similarity 175, Member A Produkte verfügbar.
Synonyme:
3830405G04Rik, 5630400M01Rik, ABRA1, AI506069, AL024423, AV118690, Ccdc98, fam175a, RGD1305287, zgc:103522
alle Proteine anzeigen Gen GeneID UniProt
FAM175A 84142 Q6UWZ7
FAM175A 70681 Q8BPZ8
FAM175A 289468 Q5I0F1

Weitere Synonyme anzeigen

Family with Sequence Similarity 175, Member A Proteine (FAM175A) nach Spezies

Wählen Sie die gewünschte Spezies

Weitere Proteine zu Family with Sequence Similarity 175, Member A Interaktionspartnern

Human Family with Sequence Similarity 175, Member A (FAM175A) Interaktionspartner

  1. Results identified 16 novel rare variants in FAM175A but no significant difference in allele frequencies between cases and controls was observed which suggest no evidence that rare variants in ABRAXAS are associated with increased breast cancer risk in the population studied.

  2. Demonstrate a mechanism involving IR-induced phosphorylation and dimerization of the BRCT/Abraxas complex for regulating Abraxas-mediated recruitment of BRCA1 in response to IR.

  3. Abraxas and RAP80 (zeige UIMC1 Proteine) were required for DNA damage resistance, G(2)-M checkpoint control, and DNA repair.

  4. CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage.

  5. CCDC98 is a mediator of BRCA1 function involved in the mammalian DNA damage response.

  6. the human Ubc13 (zeige UBE2N Proteine)/Rnf8 (zeige RNF8 Proteine) ubiquitin ligases control foci formation of the Rap80 (zeige UIMC1 Proteine)/Abraxas/Brca1/Brcc36 (zeige BRCC3 Proteine) complex in response to DNA damage

  7. Mutational analysis in 168 multiple-case breast/ovarian cancer families, negative for mutations in BRCA1 or BRCA2 (zeige BRCA2 Proteine), suggests that CCDC98 does not play an important role as a high penetrance breast cancer susceptibility gene.

  8. it seems unlikely that moderate to highly penetrant alleles of either RAP80 (zeige UIMC1 Proteine) or Abraxas, confer a significantly high relative risk of breast cancer.

  9. examined RAP80 (zeige UIMC1 Proteine) and Abraxas expression and their effect on treatment outcome in non-small-cell lung cancer

Family with Sequence Similarity 175, Member A (FAM175A) Protein Überblick

Protein Überblick

Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of brca1 (By similarity).

Alternative names and synonyms associated with Family with Sequence Similarity 175, Member A (FAM175A)

  • coiled-coil domain containing 98 (CCDC98)
  • Coiled-coil domain-containing protein 98 (ccd98)
  • family with sequence similarity 175, member A (FAM175A)
  • family with sequence similarity 175, member A (Fam175a)
  • family with sequence similarity 175, member A (fam175a)
  • 3830405G04Rik Protein
  • 5630400M01Rik Protein
  • ABRA1 Protein
  • AI506069 Protein
  • AL024423 Protein
  • AV118690 Protein
  • Ccdc98 Protein
  • fam175a Protein
  • RGD1305287 Protein
  • zgc:103522 Protein

Bezeichner auf Proteinebene für FAM175A

coiled-coil domain containing 98 , BRCA1-A complex subunit Abraxas , Protein FAM175A , abraxas protein , coiled-coil domain-containing protein 98

GENE ID SPEZIES
461205 Pan troglodytes
100194936 Salmo salar
84142 Homo sapiens
70681 Mus musculus
289468 Rattus norvegicus
504796 Bos taurus
422608 Gallus gallus
478459 Canis lupus familiaris
449820 Danio rerio
443765 Xenopus laevis
Ausgewählte Anbieter für Family with Sequence Similarity 175, Member A Proteine (FAM175A)
Haben Sie etwas anderes gesucht?