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Solute Carrier Family 13 Member 3 Proteine (SLC13A3)

Bezeichnung:
Solute Carrier Family 13 Member 3 Proteine (SLC13A3)
Auf www.antikoerper-online.de finden Sie aktuell 4 Solute Carrier Family 13 Member 3 (SLC13A3) Proteine von 2 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Solute Carrier Family 13 Member 3 Antikörper (27) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 38 Solute Carrier Family 13 Member 3 Produkte verfügbar.
Synonyme:
MGC108337, NaDC-3, Nadc3, SDCT2, SLC13A3, zgc:77173
alle Proteine anzeigen Gen GeneID UniProt
SLC13A3 64849 Q8WWT9
SLC13A3 114644 Q91Y63
Ratte SLC13A3 SLC13A3 64846  

Weitere Synonyme anzeigen

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Weitere Proteine zu Solute Carrier Family 13 Member 3 Interaktionspartnern

Human Solute Carrier Family 13 Member 3 (SLC13A3) Interaktionspartner

  1. OAT1 (zeige KCNK3 Proteine) and NaDC3 in the basolateral membrane and OAT4 (zeige SLC22A9 Proteine) in the luminal membrane of proximal tubule cells are responsible for the avid renal secretion of N-carbamoylglutamate.

  2. In a study addressing genetic, social, and environmental contributors of chronic kidney disease with tubulointerstitial damages in Sri (zeige SRI Proteine) Lanka, SNP rs6066043 of SLC13A3 was found attributable risk of 50%.

  3. study concludes NaDC3 present at the basolateral membrane of proximal tubule cells mediates sodium-dependent glutathione (GSH) uptake; the kinetic data show that NaDC3 is a low-affinity GSH transporter

  4. The data 1) reveal alpha-ketoglutarate as a common high-affinity substrate of NaDC3, OAT1 (zeige KCNK3 Proteine), and OAT3 (zeige SLC22A8 Proteine)

  5. The results indicate that SLC13A3 is a direct downstream target of PITX2 (zeige PITX2 Proteine) transcriptional regulation and that levels of PITX2 (zeige PITX2 Proteine) and SLC13A3 modulate responses to oxidative stress in ocular cells.

  6. NaDC3 promotes cellular senescence probably by inhibiting NAD(+)-dependent SIRT1 (zeige SIRT1 Proteine).

  7. The narrow substrate specificity prevents interaction of drugs with dicarboxylate-like structure with hNaDC-3 and ensures sufficient support of the proximal tubule cells with alpha-ketoglutarate for anion secretion via organic anion transporter 1 (zeige SLC22A6 Proteine) or 3.

  8. We provide direct evidence of the localization of NaDC3 at the basolateral membrane of human renal proximal tubule cells and identify a di-hydrophobic amino acid motif VW as basolateral localization signal in the N-terminal cytoplasmic domain of NaDC3.

Mouse (Murine) Solute Carrier Family 13 Member 3 (SLC13A3) Interaktionspartner

  1. demonstrate the membrane translocation of 3OH-GA mediated by NaDC3 and the cis (zeige CISH Proteine)-inhibitory effect on OCT2 (zeige SLC22A2 Proteine)-mediated transport of cations

Solute Carrier Family 13 Member 3 (SLC13A3) Protein Überblick

Protein Überblick

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet.

Alternative names and synonyms associated with Solute Carrier Family 13 Member 3 (SLC13A3)

  • solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (slc13a3)
  • solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (SLC13A3)
  • solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 (Slc13a3)
  • MGC108337 Protein
  • NaDC-3 Protein
  • Nadc3 Protein
  • SDCT2 Protein
  • SLC13A3 Protein
  • zgc:77173 Protein

Bezeichner auf Proteinebene für SLC13A3

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3 , solute carrier family 13 member 3 , Na(+)/dicarboxylate cotransporter 3 , hNaDC3 , naDC-3 , sodium-dependent high affinity dicarboxylate transporter 3 , sodium-dependent high-affinity dicarboxylate transporter 2 , mNaDC3 , rNaDC3 , sodium-dependent high-affinity dicarboxylate transporter 3

GENE ID SPEZIES
548493 Xenopus (Silurana) tropicalis
100029726 Monodelphis domestica
100071226 Equus caballus
458302 Pan troglodytes
405838 Danio rerio
444773 Xenopus laevis
770495 Gallus gallus
64849 Homo sapiens
485910 Canis lupus familiaris
526291 Bos taurus
114644 Mus musculus
64846 Rattus norvegicus
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