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Our results suggest that H19 (zeige NCKAP1 ELISA Kits) functions as a competitive endogenous RNA (ceRNA) by acting as a sink for miR-17-5p, revealing a potential ceRNA regulatory network involving H19 (zeige NCKAP1 ELISA Kits) and miR-17-5p with a role in the modulation of YES1 expression
c-Yes plays an important role in migration and invasion of epithelial ovarian cancer.
Up-regulation of miR (zeige MLXIP ELISA Kits)-210 inhibits hepatocellular carcinoma cell proliferation. Yes1 is a target of miR (zeige MLXIP ELISA Kits)-210 and affects cell proliferation in HCC (zeige FAM126A ELISA Kits).
findings indicate that miR (zeige MLXIP ELISA Kits)-203 induces the apoptosis of KB cells by directly targeting Yes-1, suggesting its application in anti-cancer therapeutics
Results demonstrate a unique role for Yes in phosphorylation of FAK (zeige PTK2 ELISA Kits) and in promoting PCa (zeige FLVCR1 ELISA Kits) metastasis. Therefore, phosphorylated FAK (zeige PTK2 ELISA Kits) Y861 and increased Yes expression may be predictive markers for PCa (zeige FLVCR1 ELISA Kits) metastasis.
results indicated that miR-17-5p might play a role in human ovarian cancer by up-regulating YES1 expression.
Increased YES/SFK activation might serve as a clinical biomarker for predicting tumor resistance to IGF-1R (zeige IGF1R ELISA Kits) inhibition.
YES1 and YAP (zeige YAP1 ELISA Kits) transcript levels were higher in liver metastases of patients with colon cancer after 5FU-based neoadjuvant chemotherapy.
YES kinase as a proximal glucose-specific signal in the Cdc42 (zeige CDC42 ELISA Kits)-signaling cascade.
we identified CRKL (zeige CRKL ELISA Kits)/YES as critical interrelated pathways necessary for rhabdomyosarcoma cell growth and survival and suggest a potential therapeutic role of SRC (zeige SRC ELISA Kits) family kinase inhibition in the treatment of rhabdomyosarcoma.
investigated signaling pathways in early development by comparison of the phosphoproteome of wild type embryos with Fyn (zeige FYN ELISA Kits)/Yes knockdown embryos that display specific convergence and extension cell movement defects
Ganglioside GD3 enhances invasiveness of gliomas by forming a complex with PDGFRalpha and Yes Kinase.
serum also activates TEAD-dependent transcription in a time- and dose-dependent manner and we identify Inter-alpha-inhibitor (IalphaI) as a component in serum capable of activating the Yes/YAP (zeige YAP1 ELISA Kits)/TEAD pathway
Differentiation of embryonic stem cells is driven by c-Src (zeige SRC ELISA Kits) is antagonized by c-Yes.
The antiapoptotic effect of YES1 activation in response to testicular heat insult may mediate via the regulation of extracellular signal-regulated kinase (ERK (zeige EPHB2 ELISA Kits))/metastasis-associated 1 (MTA1 (zeige MTA1 ELISA Kits)) cascade.
Results suggest that LKB1 (zeige STK11 ELISA Kits) inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24 (zeige CD24 ELISA Kits)(+) tumor subpopulation.
YAP (zeige YAP1 ELISA Kits), TEAD2 and Yes are highly expressed in self-renewing embryonic stem cells, and are activated by LIF (zeige LIF ELISA Kits).
eIF4E (zeige EIF4E ELISA Kits) and yes have cooperative roles in oncogenic transformation
Data show that in response to angiotensin II, the ability of ERK1/2 (zeige MAPK1/3 ELISA Kits) to remain within the cytoplasm or translocate into the nucleus is controlled by c-Src (zeige SRC ELISA Kits)/Yes/Fyn (zeige FYN ELISA Kits) or heterotrimeric G protein/PKCzeta (zeige PRKCZ ELISA Kits) signaling, respectively.
Data imply that distinct modes of spatial activation and membrane delivery, under the control of specific acylation attachment sequences and endosome sub-type requirements, define distinct properties of the three SFKs (Src (zeige SRC ELISA Kits) family kinases).
Binding of CD95 Ligand (zeige FASL ELISA Kits) to CD95 (zeige FAS ELISA Kits) on glioblastoma cells recruit Yes and the p85 (zeige ECM1 ELISA Kits) subunit of phosphatidylinositol 3-kinase to CD95 (zeige FAS ELISA Kits), which signal invasion via the glycogen synthase kinase 3-beta (zeige GSK3b ELISA Kits) pathway and subsequent expression of matrix metalloproteinases.
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.
viral oncogene yes-1 homolog 1
, v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
, tyrosine-protein kinase Yes
, viral oncogene yes-1 homolog 1-like
, proto-oncogene tyrosine-protein kinase Yes-like
, Yamaguchi sarcoma oncogene
, cellular yes-1 protein
, proto-oncogene c-Yes
, proto-oncogene tyrosine-protein kinase YES
, protein-tyrosine kinase
, tyrosine-protein kinase yes
, c-yes proto-oncogene
, proto-oncogene tyrosine-protein kinase Yes
, viral oncogene yes homolog
, Yamagichi sarcoma viral (v-yes-1) oncogene homolog 1
, Yamaguchi sarcoma viral oncogene homolog 1