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Data show that single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) forms a tetramer and is stabilized by two cysteines (C81 and C99) as well as a subset of charged and hydrophobic residues.
DNA synthesis determines the binding mode of the human mtSSB.
The data presented in this study suggests that while SSBP1 has predominantly been considered in a DNA repair context, it is likely to have roles in many other cellular processes. In particular, the identification of numerous proteins with roles in mRNA metabolism, transcriptional transactions and ribosomal processes, may suggest these as important areas of SSBP1 function.
Data suggest that human mitochondrial SSB shares many physicochemical properties with E coli SSB and that the differences may be explained by the lack of an acidic, disordered C-terminal tail in human mitochondrial SSB protein. (SSB = single-stranded DNA-binding protein (zeige RPA1 Proteine))
Data suggest that human mitochondrial SSB and E coli SSB both protect and expose single-stranded DNA; implications from these studies toward understanding DNA replication and DNA repair abound. (SSB = single-stranded DNA-binding protein (zeige RPA1 Proteine)) [EDITORIAL]
hSSB1 is directly phosphorylated by DNA-PK at serine residue 134. While this modification is largely suppressed in undamaged cells by PPP-family protein phosphatases, S134 phosphorylation is enhanced following the disruption of replication forks and promotes cellular survival.
The stimulatory effect of mtSSB on Pol gamma (zeige POLG Proteine) on these ssDNA templates is not species-specific.
This study determined that hSSB1 acetylation at K94 mediated by the acetyltransferase p300 and the deacetylases SIRT4 and HDAC10 impaired its ubiquitin-mediated degradation by proteasomes.
SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 (zeige HSF1 Proteine) transcriptional activity
Fbxl5 (zeige FBXL5 Proteine) interacts with and targets hSSB1 for ubiquitination and degradation, which could be prevented by ATM (zeige ATM Proteine)-mediated hSSB1 T117 phosphorylation.
SSBp1 deletion results in increased chromosomal aberrations and localizes to telomeres and participate in the repair of uncapped telomeres.
overexpression of Mitogenin I (zeige POLDIP2 Proteine) or mitochondrial single-stranded DNA-binding protein (zeige RPA1 Proteine) increased elongated or fragmented mitochondria in mouse C2C12 myoblast cells, respectively.
SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995
PWP1-interacting protein 17
, single-stranded DNA-binding protein, mitochondrial
, single strand DNA-binding protein P16
, single-stranded DNA binding protein 1
, Oligonucleotide/oligosaccharide-binding fold containing 2B-A
, SOSS complex subunit B1-A
, nucleic acid-binding protein 2-A
, oligonucleotide/oligosaccharide-binding fold containing 2B
, oligonucleotide/oligosaccharide-binding fold-containing protein 2B-A
, sensor of single-strand DNA complex subunit B1-A
, sensor of ssDNA subunit B1-A
, single-stranded DNA-binding protein 1-A