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This search revealed that rare mutations that disable one copy of a gene called SMAD6 in combination with a common DNA variant near another gene called BMP2 (zeige BMP2 Proteine) account for about 7% of infants with midline forms of craniosynostosis.
Single Nucleotide Polymorphisms in SMAD6 gene is associated with brain metastasis in non-small-cell lung cancer
monoubiquitinated SMAD6 impairs the binding affinity of non-modified SMAD6 to the BMP type I receptor. Moreover, UBE2O (zeige UBE2O Proteine) and SMAD6 cooperated in the regulation of BMP7 (zeige BMP7 Proteine)-induced adipogenesis
Smad6 indirectly maintains stemness by preventing spontaneous erythropoiesis in hematopoietic stem cells.
Loss of SMAD6 is associated with lung adenocarcinoma.
Congenital cardiovascular malformation is related to genetic variation in SMAD6
Haplotype analysis further revealed that two haplotype blocks within SMAD6 were significantly associated with decreased ovarian cancer risk, as compared to the most common haplotype.
results suggest that MyD88 (zeige MYD88 Proteine) degradation driven by the Smad6-Smurf pathway is a novel mechanism for TGF-beta1 (zeige TGFB1 Proteine)-mediated negative regulation of MyD88 (zeige MYD88 Proteine)-dependent pro-inflammatory signalling
Data show that Runx1 (zeige RUNX1 Proteine), in conjunction with Fli1 (zeige FLI1 Proteine), Gata2 (zeige GATA2 Proteine), and Scl (zeige KRT7 Proteine), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.
Smad6 and Smad7, inhibitors of BMP signaling, were up-regulated in HFE-mutant hereditary hemochromatosis compared to controls, disruptin bone morphogenic protein signaling.
A complex form of acute rheumatic heart disease with tissue hardening is seen in the absence of either Smad-6 (or NKX2-5 (zeige NKX2-5 Proteine)).
These results indicate that PRIP (zeige NCOA6 Proteine) is implicated in BMP-induced osteoblast differentiation by the negative regulation of Smad (zeige SMAD1 Proteine) phosphorylation, through the methylation of inhibitory Smad6
These findings suggest that TNF-alpha (zeige TNF Proteine) induces valvular and vascular cell calcification, in part, by specifically reducing the expression of a BMP-2 (zeige BMP2 Proteine) signaling inhibitor, Smad6.
The Smad6 is a novel target of Arkadia (zeige RNF111 Proteine), and that Arkadia (zeige RNF111 Proteine) positively regulates BMP signalling via degradation of Smad6, Smad7 (zeige SMAD7 Proteine) and c-Ski (zeige SKI Proteine)/SnoN (zeige SKIL Proteine).
Smad6 inhibits non-canonical TGF-beta1 (zeige TGFB1 Proteine) signaling by recruiting the deubiquitinase A20 (zeige TNFAIP3 Proteine) to TRAF6 (zeige TRAF6 Proteine).
Hepcidin (zeige HAMP Proteine), Smad6 and Smad7 (zeige SMAD7 Proteine) mRNA expression is coordinated in a way that it correlates with the activity of the Bmp/Smad (zeige SMAD1 Proteine) signaling pathway.
Sema7A (zeige SEMA7A Proteine) positively regulates the production of transforming growth factor (TGF)-beta1 (zeige TGFB1 Proteine) and Smad6 to facilitate West Nile virus pathogenesis in mice.
Results indicate that peptidyl-prolyl isomerase Pin1 (zeige PIN1 Proteine) Associates with Smad3 (zeige SMAD3 Proteine) and Smad6.
Data show that Runx1 (zeige RUNX1 Proteine), in conjunction with Fli1 (zeige FLI1 Proteine), Gata2 (zeige GATA2 Proteine), and Scl (zeige TAL1 Proteine), directly regulates the expression of Smad6 in the aorta-gonad-mesonephros region in the developing embryo, where hematopoietic stem cells originate.
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila 'mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.
SMAD, mothers against DPP homolog 6
, MAD homolog 6
, Mothers against decapentaplegic, drosophila, homolog of, 6
, SMAD 6
, mothers against DPP homolog 6
, mothers against decapentaplegic homolog 6
, Smad 6
, mad homolog 7
, MAD, mothers against decapentaplegic homolog 6