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Results showed a significant higher FOXC1 expression in estrogen receptor (zeige ESR1 ELISA Kits)-negative breast cancer than that in estrogen receptor (zeige ESR1 ELISA Kits)-positive. Its overexpression reduced expression of ERalpha (zeige ESR1 ELISA Kits) and cellular responses to tamoxifen suggesting that FOXC1 regulated expression of ERalpha (zeige ESR1 ELISA Kits) and affected sensitivity of tamoxifen treatment in breast cancer
present work reveals that FOXC1 is an important regulator of exocytosis and establishes a new link between FOXC1 and MYOC (zeige MYOC ELISA Kits)-associated glaucoma
Glaucoma prevalence and phenotype are characterized in a cohort of glaucoma patients and their family members with FOXC1 variants.
FOXC1 and FOXC2 (zeige FOXC2 ELISA Kits) are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases
This review will summarize current knowledge on the function and regulation of FOXC1 in tumor development and progression with a focus on basal-like breast cancer, as well as the implications of these new findings in cancer diagnosis and treatment. [review]
Here, we demonstrate a novel FOXC1-driven mechanism that suppresses ERa expression in breast cancer. We find that FOXC1 competes with GATA-binding protein 3 (GATA3 (zeige GATA3 ELISA Kits)) for the same binding regions in the cis (zeige CISH ELISA Kits)-regulatory elements upstream of the ERa gene and thereby downregulates ERa expression and consequently its transcriptional activity
A novel heterozygous FOXC1 variant segregated with the disease in a family with Axenfeld Rieger Syndrome. A novel homozygous variant in the FOXC1 gene segregated in a family with ARS (zeige SLURP1 ELISA Kits) and congenital glaucoma.
Our findings suggested that FOXCUT expression contributed to the development and progression of nasopharyngeal carcinoma by targeting FOXC1 and that FOXCUT might be useful as a potential nasopharyngeal carcinoma biomarker and therapeutic target.
this study defines FOXC1 as a regulator specific for KC terminal differentiation and establishes its potential position in the genetic regulatory network.
FOXC1 is correlated with chemosensitivity to anthracycline and could be used as an indicator of chemosensitivity in sporadic triple-negative breast cancer
These data indicate that Foxc1 expression is regulated by BMP4 (zeige BMP4 ELISA Kits) and FOXC1 functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds.
Foxc1 regulates sweat duct luminal cell differentiation and mimic apocrine miliaria.
Compound, NC-specific Foxc1; Foxc2 (zeige FOXC2 ELISA Kits) homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2 (zeige PITX2 ELISA Kits), and its downstream effector Dkk2 (zeige DKK2 ELISA Kits), which antagonizes canonical Wnt (zeige WNT2 ELISA Kits) signaling.
These findings offer the first evidence for a role of the meninges in brain vascular development and provide new insight into potential causes of cerebrovascular defects in patients with FOXC1 mutations.
Foxc1 and Foxc2 (zeige FOXC2 ELISA Kits) maintain glomerular podocyte integrity by regulating the gene expression.
Foxc1 and Foxc2 (zeige FOXC2 ELISA Kits) have a role in kidney and axial skeleton development.
FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.FOXC1 is necessary to establish a multiple-bulge hair follicle architecture.
deletion of Foxc1 and Foxc2 (zeige FOXC2 ELISA Kits) specifically in Pax3 (zeige PAX3 ELISA Kits)-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb
Foxc1 is an important transcriptional partner of Ihh (zeige IHH ELISA Kits)-Gli2 (zeige GLI2 ELISA Kits) signalling during endochondral ossification, and that disruption of the Foxc1-Gli2 (zeige GLI2 ELISA Kits) interaction causes skeletal abnormalities observed in the Axenfeld-Rieger syndrome.
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined\; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.
forkhead box protein C1
, forkhead box C1
, Forkhead box protein C1
, forkhead, drosophila, homolog-like 7
, forkhead-related activator 3
, forkhead-related protein FKHL7
, forkhead-related transcription factor 3
, forkhead/winged helix-like transcription factor 7
, myeloid factor-delta
, congenital hydrocephalus
, mesoderm/mesenchyme forkhead 1
, transcription factor FKH-1
, forkhead box protein C1-B
, winged helix protein CWH-6
, winged-helix transcription factor