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centromere assembly factors CAL1 (zeige CALCA ELISA Kits) and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility
identify two co-evolving regions, CENP-A L1 and the CAL1 (zeige CALCA ELISA Kits) N terminus, as critical for lineage-specific CENP-A incorporation
A novel role has been described for the histone acetyltransferase (zeige HAT ELISA Kits) Hat1 (zeige HAT1 ELISA Kits) in the CENP-A/CID assembly pathway in Drosophila melanogaster.
CENP-A assembly by its loading factor, CAL1, requires RNAPII-mediated transcription of the underlying DNA
The amount of Cid that is loaded during each cell cycle appears to be determined primarily by the preexisting centromeric Cid, with little flexibility for compensation of accidental losses.
CID nucleosomes are octameric in vivo and that CID dimerization is essential for correct centromere assembly.
The F box protein (zeige FBXO30 ELISA Kits) partner of paired (Ppa (zeige FBXL14 ELISA Kits)) mediates CenH3(CID) stability in Drosophila. Ppa (zeige FBXL14 ELISA Kits) depletion results in increased CenH3(CID) levels. Ppa (zeige FBXL14 ELISA Kits) physically interacts with CenH3(CID) through the CATD (zeige CTSD ELISA Kits)(CID) that mediates Ppa (zeige FBXL14 ELISA Kits)-dependent CenH3(CID) stability.
Drosophila CENP-C is essential for centromere identity.
Cid allows for contacts betwen DNA and histones and specific targeting
Results suggest that CID mislocalization promotes formation of ectopic centromeres and multicentric chromosomes, which causes chromosome missegregation, aneuploidy, and growth defects.
Upon cross-linking, the entire CENPA/CENPB (zeige CENPB ELISA Kits)/CENPC (zeige CENPC1 ELISA Kits)/CENPT (zeige CENPT ELISA Kits) complex is nuclease (zeige DCLRE1C ELISA Kits)-protected over an alpha-satellite dimer that comprises the fundamental unit of centromeric chromatin. We conclude that CENPA/CENPC and CENPT (zeige CENPT ELISA Kits) pathways for kinetochore assembly are physically integrated over young alpha-satellite dimers.
we review our current understanding of CENP-A evolution in relation to centromere drive and discuss classical and recent advances, including new evidence implicating CENP-A chaperones in this conflict.
there is a reciprocal interdependency of CENP-A chromatin and the underlying repetitive centromere DNA sequences bound by CENP-B (zeige CENPB ELISA Kits) in the maintenance of human chromosome segregation.
Identify the licensing factor M18BP1 and the CENP-A chaperone HJURP as the two key targets of Cdk (zeige CDK4 ELISA Kits)-based inhibition sufficient for maintenance of strict cell-cycle control of CENP-A assembly.
CENP-A specifically binds alpha satellite non-coding RNAs. Loss of CENP-A does not affect transcript abundance or stability.
Evolutionarily conserved flexible ends of the CENP-A nucleosomes are essential to ensure the fidelity of the mitotic pathway.
These data implicate the insulin (zeige INS ELISA Kits)-FoxM1 (zeige FOXM1 ELISA Kits)/PLK1 (zeige PLK1 ELISA Kits)/CENP-A pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
Findings indicate that expression of the scleroderma autoantigens IFI-16 (zeige IFI16 ELISA Kits) and CENPs (zeige APITD1 ELISA Kits), which are associated with severe vascular disease, is increased in vascular progenitors and mature endothelial cells. High level, lineage-enriched expression of autoantigens may explain the striking association between clinical phenotypes and the immune targeting of specific autoantigens.
KAT7 (zeige MYST2 ELISA Kits)-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1 (zeige SUV39H1 ELISA Kits)-mediated heterochromatin invasion into centromeres.
CENP-A mutants that cannot be phosphorylated at Ser68 or ubiquitinated at Lys124 assemble efficiently at centromeres during G1, mediate early events in centromere establishment at an ectopic chromosomal locus, and maintain centromere function indefinitely.
evolutionarily conserved flexible ends of the CENP-A nucleosomes are essential to ensure the fidelity of the mitotic pathway.
CPCs maintain relatively high levels of CENP-A early in life, which is necessary for sustaining proliferation, inhibiting senescence, and promoting survival following differentiation of CPCs.
Results report that the level of CENP-A, a protein required for cell division, declines precipitously with age in an islet-specific manner.
Cenpa, Cenpb (zeige CENPB ELISA Kits), and Bub3 (zeige BUB3 ELISA Kits), but not Cenpc (zeige CENPC1 ELISA Kits), interacted with PARP-1 (zeige PARP1 ELISA Kits)
The centromere-targeting domain of CENP-A is both necessary and sufficient for recruitment to double-strand breaks. CENP-A accumulation at DNA breaks is enhanced by active non-homologous end-joining but does not require DNA-PKcs (zeige PRKDC ELISA Kits) or Ligase IV.
CENP-C (zeige CENPC1 ELISA Kits) and M18BP1 recruit HJURP to centromeres for new CENP-A assembly.
CENP-A assembly into chromatin requires unidentified deoxycytidine deaminase (zeige APOBEC3G ELISA Kits) and UNG2 (zeige CCNO ELISA Kits), a uracil DNA glycosylase (zeige UNG ELISA Kits).
CENP-A deposition at the centromeres is dependent on HJURP.
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
, centromere identifier protein
, centromere protein A
, centromere protein-A
, centromere protein, Xenopus
, histone H3-like centromeric protein A
, centromeric histone-3 like protein
, centromere autoantigen A
, centromere protein A, 17kDa
, centromere-specific histone
, centrosomin A