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Human Polyclonal TSPO Primary Antibody für ICC, IF - ABIN188570
Fafalios, Akhavan, Parwani, Bies, McHugh, Pflug: Translocator protein blockade reduces prostate tumor growth. in Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Show all 7 Pubmed References
Human Polyclonal TSPO Primary Antibody für IHC, WB - ABIN222898
Ji, Maeda, Sawada, Ono, Okauchi, Inaji, Zhang, Suzuki, Ando, Staufenbiel, Trojanowski, Lee, Higuchi, Suhara: Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2008
Mouse (Murine) Polyclonal TSPO Primary Antibody für ELISA, WB - ABIN570960
Morgan, Cheepala, Wang, Neale, Adachi, Nachagari, Leggas, Zhao, Boyd, Venkataramanan, Schuetz: Deregulated hepatic metabolism exacerbates impaired testosterone production in Mrp4-deficient mice. in The Journal of biological chemistry 2012
Mouse (Murine) Polyclonal TSPO Primary Antibody für ELISA, WB - ABIN4343998
Weisinger, Kelly-Hershkovitz, Veenman, Spanier, Leschiner, Gavish: Peripheral benzodiazepine receptor antisense knockout increases tumorigenicity of MA-10 Leydig cells in vivo and in vitro. in Biochemistry 2004
Human Polyclonal TSPO Primary Antibody für IHC, WB - ABIN4343997
Foss, Liu, Mease, Wang, Pasricha, Pomper: Imaging Macrophage Accumulation in a Murine Model of Chronic Pancreatitis with (125)I-Iodo-DPA-713 SPECT/CT. in Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2017
Results showed that TSPO and other mitophagy related proteins, such as VDAC1 (zeige VDAC1 Antikörper), Pink1 (zeige PINK1 Antikörper) and Beclin1 (zeige BECN1 Antikörper) were significantly decreased by LH challenge. Moreover, KIFC2 (zeige KIFC2 Antikörper), relevant to the mitochondrial transport and Snap25 (zeige SNAP25 Antikörper), relevant to neurotransmitter vesicle release, were also obviously down-regulated in the LH mice, which further rendered supportive evidence for the existing mitochondrial dysfunction in LH mice.
A potential modulatory role of TSPO is in response to immune system deficit.
The expression of TSPO was found to be increased in the peri (zeige POSTN Antikörper)-hematomal brain region after intracerebral hemorrhage.
TSPO expression increases ( approximately 9-fold) in rodent-derived macrophages and microglia upon pro-inflammatory stimulation.
Data suggest that up-regulation of translocator protein 18kDa level during neuroinflammation may be an adaptive response mechanism, a way to provide more neurosteroids.
This study confirms TSPO deficiency does not affect viability and bronchial alveolar immune homeostasis.
These results suggested that Wuling powder exhibited an obvious antidepressant effect, which could be due to the improvement of TSPO-mediated mitophagy signaling pathway.
The loss of TSPO in the Central Nervous System did not result in overt developmental defects or phenotypes. The TSPO-/- mouse showed a decrease in glial fibrillary acidic protein (zeige GFAP Antikörper) expression, correlating with a decrease in astrogliosis in response to neural injury during Autoimmune Experimental Encephalomyelitis.
Study reviews the physiological functions of TSPO gene in the mitochondrial permeability transition pore, steroidogenesis and energy metabolism especially in knockout mice. [review]
Study highlights the 3D structure of mTSPO/PBR and in complex with PK11195 providing an important step towards a more detailed understanding of the molecular mechanism of mammalian TSPO/PBR and its interaction with small molecules. [review]
Genome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P < 5 x 10(-8)) were identified for SNPs in PFDN1/HBEGF, USP6NL/ECHDC3, and BZRAP1-AS1.
TSPO mutations in rats and a human polymorphism impair the rate of steroid synthesis.
Findings suggest lower glial density or an altered activation state with lower TSPO expression in the hippocampus of alcohol dependent patients.
demonstrate a consistent down-regulation of TSPO mRNA and protein in macrophages activated to a pro-inflammatory, or 'M1' phenotype
These findings have important implications for understanding the biology of TSPO in activated macrophages and microglia in humans.
TSPO may serve a range of functions that can be viewed as downstream regulatory effects of its primary, evolutionary conserved role in cell metabolism and energy production.
We report for the first time, to our knowledge, the kinetic properties of the novel third-generation TSPO PET ligand (18)F-GE180 in humans: 2TCM4k is the optimal method to quantify the brain uptake, 90 min is the optimal scan length, and the Logan approach could be used to generate parametric maps. Although these control subjects have shown relatively low VT, the methodology presented here forms the basis for quantificati
demonstrate rapid decrease in TSPO binding to the high affinity site induced by exposure to cigarette smoke
Study shows that TSPO's mitochondrial functions include modulation of nuclear gene expression via mitochondrial-nuclear signaling which can suggests whereby TSPO can control several vital cell functions, which has major implications for the whole organism in health and disease.
TSPO is an ancient bacterial receptor/stress sensor that has developed additional interactions, partners, and roles in its mitochondrial outer membrane environment in eukaryotes.
PBR mRNA was the more abundant detected form in pig tissues and in warm kidney that underwent ischemia suggesting functional implications of PBR during the renal repair process.
Changes in TSPO expression in kidney regenerating tissue could be important for renal protection and maintenance of kidney function.
Present mainly in the mitochondrial compartment of peripheral tissues, the protein encoded by this gene interacts with some benzodiazepines and has different affinities than its endogenous counterpart. The protein is a key factor in the flow of cholesterol into mitochondria to permit the initiation of steroid hormone synthesis. Alternatively spliced transcript variants have been reported\; one of the variants lacks an internal exon and is considered non-coding, and the other variants encode the same protein.
peripheral-type benzodiazepine receptor
, Peripheral-type benzodiazepine receptor
, translocator protein
, benzodiazepine receptor, peripheral
, isoquinoline-binding protein
, mitochondrial benzodiazepine receptor
, Benzodiazepin receptor (peripheral)
, benzodiazepine peripheral binding site
, peripheral benzodiazepine receptor
, benzodiazepine receptor (peripheral)