anti-Human Lipocalin 2 Antikörper für Immunofluorescence (Paraffin-embedded Sections)

Recommended Lipocalin 2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Lipocalin 2 (LCN2) Antikörper
  • LCN2
  • 24p3
  • MSFI
  • NGAL
  • AW212229
  • Sip24
  • lipocalin 2
  • lipocalin 2-like
  • LCN2
  • Lcn2
  • LOC100352980
Epitop
AA 147-166
21
19
19
14
13
13
7
5
5
4
3
2
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
304
116
108
40
30
2
1
1
Wirt
Kaninchen
210
188
44
36
3
2
Klonalität
Polyklonal
Konjugat
Unkonjugiert
57
28
21
9
7
7
7
6
6
6
6
6
6
6
6
6
6
6
3
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
338
332
137
107
29
26
21
17
12
7
5
4
4
2
2
2
2
2
1
1
1
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN685627
$ 307.45
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2803786 IF (p) Alexa Fluor 594 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN685631 IF (p) Cy5 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN685630 IF (p) Cy3 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN685632 IF (p) Cy5.5 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN685633 IF (p) Cy7 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN685634 IF (p) FITC Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN908241 IF (p) Alexa Fluor 488 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN908242 IF (p) Alexa Fluor 555 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN908240 IF (p) Alexa Fluor 647 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN908238 IF (p) Alexa Fluor 350 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN5006205 IF (p) Alexa Fluor 680 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal
1 ABIN5006206 IF (p) Alexa Fluor 750 Rabbit IgG AA 147-166 Anmelden zum Anzeigen Polyclonal

General

Antigen Lipocalin 2 (LCN2) Antikörper
Epitop AA 147-166
(21), (19), (19), (14), (13), (13), (7), (5), (5), (4), (3), (2), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(304), (116), (108), (40), (30), (2), (1), (1)
Wirt Kaninchen
(210), (188), (44), (36), (3), (2)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(57), (28), (21), (9), (7), (7), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(338), (332), (137), (107), (29), (26), (21), (17), (12), (7), (5), (4), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human Lipocalin 2
Isotyp IgG

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung Lipocalin 2 (LCN2 Antibody Abstract)
Hintergrund

Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.

Subcellular location: Secreted

Synonyms: 24p3, MSFI, NGAL, Neutrophil gelatinase-associated lipocalin, 25 kDa alpha-2-microglobulin-related subunit of MMP-9, Lipocalin-2, Oncogene 24p3, Siderocalin LCN2, p25, LCN2, HNL

Gen-ID 3934
UniProt P80188
Forschungsgebiet Cancer, Metabolism, Fatty Acids, Adaptive Immunity
Pathways Cellular Response to Molecule of Bacterial Origin, Transition Metal Ion Homeostasis

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikationshinweise IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Xu, Zhang, Cheng, Liu, Zou, Zhan, Xiao, Xia: "Transcription factor 7-like 1 dysregulates keratinocyte differentiation through upregulating lipocalin 2." in: Cell death discovery, Vol. 2, pp. 16028, 2016

Xing, Wang, Cheng, Montaner, Mandeville, Leung, van Leyen, Lok, Wang, Lo: "Neuronal production of lipocalin-2 as a help-me signal for glial activation." in: Stroke; a journal of cerebral circulation, Vol. 45, Issue 7, pp. 2085-92, 2014

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Lipocalin 2 (LCN2) (AA 147-166) antibody (ABIN685627) Formalin-fixed and paraffin embedded human colon carcinoma labeled with Rabbit Anti N...
Immunofluorescence (IF) image for anti-Lipocalin 2 (LCN2) (AA 147-166) antibody (ABIN685627) Formalin-fixed and paraffin-embedded human brain labeled with Rabbit Anti-NGAL Polycl...
ELISA image for anti-Lipocalin 2 (LCN2) (AA 147-166) antibody (ABIN685627) Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:1...
Immunofluorescence (IF) image for anti-Lipocalin 2 (LCN2) (AA 147-166) antibody (ABIN685627) Formalin-fixed and paraffin-embedded human brain labeled with Rabbit Anti-NGAL Polycl...