Chemokine (C-C Motif) Ligand 2 Proteine (CCL2)

Auf www.antikoerper-online.de finden Sie aktuell 130 Chemokine (C-C Motif) Ligand 2 (CCL2) Proteine von 20 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Chemokine (C-C Motif) Ligand 2 Antikörper (559) und Chemokine (C-C Motif) Ligand 2 Kits (191) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 902 Chemokine (C-C Motif) Ligand 2 Produkte verfügbar.
Synonyme:
AI323594, GDCF-2, HC11, HSMCR30, JE, MCAF, MCP-1, MCP-1A, MCP1, MCP1A, SCYA2, Sigje, SMC-CF
alle Proteine anzeigen Gen GeneID UniProt
CCL2 24770 P14844
CCL2 6347 P13500
CCL2 20296 P10148

Chemokine (C-C Motif) Ligand 2 Proteine (CCL2) nach Spezies

Weitere Proteine zu Chemokine (C-C Motif) Ligand 2 Interaktionspartnern

Human Chemokine (C-C Motif) Ligand 2 (CCL2) Interaktionspartner

  1. a molecular mechanism of oxidized low density lipoprotein antibody on inhibition of oxLDL-induced ERK MAPK (zeige MAPK1 Proteine) pathway and consequent MCP-1 release.

  2. tumor-promoting role for CCL2 acting through CCR2 on the tumor microenvironment

  3. conclude that MCP-1/CCL2 plays a significant role in the pathogenesis of sepsis, which has potentially important therapeutic implications

  4. Data suggest that MCP1/CCL2 induces activation/tyrosine phosphorylation of ARHGEF1/p115-RhoGEF (zeige ARHGEF1 Proteine) and up-regulates RAC1 signaling in vascular smooth muscle cells (VSMCs); ARHGEF1 (zeige ARHGEF1 Proteine) inhibition suppresses MCP1-induced VSMC migration and proliferation. (ARHGEF1 (zeige ARHGEF1 Proteine) = Rho guanine nucleotide exchange factor 1 (zeige ARHGEF1 Proteine); RAC1 = Rac (zeige AKT1 Proteine) family small GTPase (zeige RACGAP1 Proteine) 1; CCL2 = C-C motif chemokine ligand 2 (zeige CXCL2 Proteine))

  5. A polarized secretion assay suggested that the silencing of endothelial myeloid-secretory impairs T effector transendothelial migration by reducing the preferential secretion of endothelial-produced CCL2

  6. In cultured macrophages, LPS (zeige IRF6 Proteine)-induced expression of monocyte chemoattractant protein (MCP)-1 was suppressed by NaN3 through inhibition of STAT1 (zeige STAT1 Proteine) and IkappaBzeta (zeige NFKBIZ Proteine) activities.

  7. CCL2/CCR2 (zeige CCR2 Proteine) axis is expressed in the majority of monocytoid Acute myeloid leukemia (zeige BCL11A Proteine) blasts

  8. identified CCL2 as a novel KIT D816V-dependent key regulator of vascular cell migration and angiogenesis in systemic mastocytosis

  9. This study establishes ECL1i as the first allosteric inhibitor of CCR2 with functional selectivity.

  10. Constitutive expression of CCL2 by the mouse mammary epithelium induces a state of low level chronic inflammation that increases stromal density and elevates cancer risk. We propose that CCL2-driven inflammation contributes to the increased risk of breast cancer observed in women with high mammographic density.

Mouse (Murine) Chemokine (C-C Motif) Ligand 2 (CCL2) Interaktionspartner

  1. this study demonstrates that killed probiotics can reduce viral disease severity and identify that the MCP-1 (zeige CPT1B Proteine) pathway might act as a key mediator in the improved antiviral immune response

  2. tumor-promoting role for CCL2 acting through CCR2 on the tumor microenvironment

  3. type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine (zeige CCL1 Proteine) expression including CCL2.

  4. In cultured macrophages, LPS (zeige TLR4 Proteine)-induced expression of monocyte chemoattractant protein (MCP)-1 (zeige CPT1B Proteine) was suppressed by NaN3 through inhibition of STAT1 (zeige STAT1 Proteine) and IkappaBzeta (zeige NFKBIZ Proteine) activities.

  5. study concludes that CCL2 signaling onto melanin-concentrating hormone (zeige PMCH Proteine) neurons represents a core mechanism that relays peripheral inflammation to sickness behavior

  6. The increased migratory phenotypes are dependent on secreted factors, including the cytokine interleukin-6 (zeige IL6 Proteine) and the chemokine (zeige CCL1 Proteine) CCL2. We propose that Delta122p53 (and Delta133p53) acts in a similar manner to 'gain-of-function' mutant p53 (zeige TP53 Proteine) proteins to promote migration, invasion and metastasis, which may contribute to poor survival in patients with Delta133p53-expressing tumours

  7. CCL5 (zeige CCL5 Proteine) paradoxically limits macrophage accumulation in the injured kidney during renin (zeige REN Proteine) angiotensin system (RAS) activation by constraining the proinflammatory actions of CCL2.

  8. This study establishes ECL1i as the first allosteric inhibitor of CCR2 with functional selectivity.

  9. Constitutive expression of CCL2 by the mouse mammary epithelium induces a state of low level chronic inflammation that increases stromal density and elevates cancer risk. We propose that CCL2-driven inflammation contributes to the increased risk of breast cancer observed in women with high mammographic density.

  10. the individual and combined actions of CCL2/CCR2 (zeige CCR2 Proteine) and CX3CL1 (zeige CX3CL1 Proteine)/CX3CR1 (zeige CX3CR1 Proteine) in hypoxia-induced pulmonary hypertension in mice, is reported.

Cow (Bovine) Chemokine (C-C Motif) Ligand 2 (CCL2) Interaktionspartner

  1. resence of type 2 diabetes negatively affects the work of cytokines and markers of fibrosis, as evidenced by higher levels of interleukin-1beta and monocyte chemoattractant protein-1, compared with patients without diabetes

  2. Studied SNPs in the bovine toll-like receptor 4 (TLR4 (zeige TLR4 Proteine)) and monocyte chemo attractant protein-1(CCL2) genes.

  3. The LEP (zeige LEP Proteine), IGF2 and CCL2 genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.

  4. immune cells and endothelial cells can interact cooperatively to increase CCL2 secretion in the corpus luteum

Rabbit Chemokine (C-C Motif) Ligand 2 (CCL2) Interaktionspartner

  1. Data show that peripheral blood endothelial progenitor cells can increase the expressions of chemokines CCL2 and CXCL12 (zeige CXCL12 Proteine) and promote the migration of enhanced green fluorescent protein-positive bone marrow stromal cells to bone defect site.

  2. In a cerebral aneurysm, expression of MCP1 peaked after induction for one week, then decreased. MCP1 induced macrophage adhesion and infiltration in the artery wall of aneurysms, and contributed to the occurrence and development of brain aneurysm.

  3. Data show that the serum levels of mast cell tryptase, monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8 (zeige IL8 Proteine)) decreased significantly in Dachengqi decoction treatment group.

  4. measurements of CCL2 and macrophages can serve as new inflammatory biomarkers to evaluate the safety of promising novel microbicides for prevention of HIV.

  5. Expression of MCP-1 was successfully inhibited by transfecting MCP-1 siRNA expression plasmid to the carotid artery, and the progression of atherosclerosis was restricted by RNAi-mediated silencing of MCP-1 expression.

Pig (Porcine) Chemokine (C-C Motif) Ligand 2 (CCL2) Interaktionspartner

  1. CXCL10 (zeige CXCL10 Proteine) protein was detected in serum from pigs infected with a high virulence African swine fever virus isolate. Levels of CCL2 mRNA were increased in pigs infected with the high virulence isolate compared to a low virulence isolate.

  2. Porcine CCL2 binding on Tuk4+SLA (zeige SLA Proteine)-II- but not on Tuk4-SLA (zeige SLA Proteine)-II+ cells was detected by using a CCL2-green fluorescence protein fusion protein.

  3. The protective properties of flavonoids, such as EGCG, against endothelial inflammation may be regulated in part though induction of HO-1 and subsequent activator protein-1 signaling.

  4. MCP-1 contributes to functional and structural impairment in the kidney in renal artery stenosis, mainly in the tubulointerstitial compartment

  5. Contrast media did not affect bone marrow cell viability/MCP-1 secretion.

  6. Porcine vessel wall injury via balloon arthroplasty upregulates expression of CCL2 by coronary artery transmural and perivascular cells in a sequential pattern.

  7. in the aortic arch expression of monocyte chemoattractant protein 1 (MCP-1) was upregulated, compared with the thoracic aorta

  8. Variable gene expression (eg, matrix metalloproteinase-9 (zeige MMP9 Proteine), CCL2 and Lp-PLA(2 (zeige Lp-PLA2 Proteine)) mRNAs), both in regard to the arterial bed and duration of disease, was associated with variable plaque development and progression.

  9. myocardial infarction induced proinflammatory gene and protein expression in peripheral blood mononuclear cells of tissue factor (zeige F3 Proteine) cyclo-oxygenase-2, monocyte chemoattractant protein-1 and CRP (zeige CRP Proteine)

Chemokine (C-C Motif) Ligand 2 (CCL2) Protein Überblick

Protein Überblick

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4.

Alternative names and synonyms associated with Chemokine (C-C Motif) Ligand 2 (CCL2)

  • chemokine (C-C motif) ligand 2 (CCL2)
  • chemokine (C-C motif) ligand 2 (Ccl2)
  • macrophage cationic peptide 1 (MCP-1)
  • mast cell proteinase-1 (MCP1)
  • AI323594 Protein
  • GDCF-2 Protein
  • HC11 Protein
  • HSMCR30 Protein
  • JE Protein
  • MCAF Protein
  • MCP-1 Protein
  • MCP-1A Protein
  • MCP1 Protein
  • MCP1A Protein
  • SCYA2 Protein
  • Sigje Protein
  • SMC-CF Protein

Bezeichner auf Proteinebene für CCL2

small inducible cytokine A2 , C-C motif chemokine 2 , immediate-early serum-responsive JE protein , immediate-early serum-responsive protein JE , monocyte chemoattractant protein 1 , monocyte chemoattractant protein-1 , monocyte chemotactic protein 1 , small inducible gene JE , small-inducible cytokine A2 , monocyte chemotactic and activating factor , monocyte secretory protein JE , small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je) , small inducible cytokine subfamily A (Cys-Cys), member 2 , platelet-derived growth factor-inducible protein JE , acidic seminal fluid protein , monocyte chemotactic protein 1A , MCP-1 , chemokine CCL2/MCP-1 , CS-III , NP-1 , antiadrenocorticotropin peptide III , corticostatin III , corticostatin-3 , macrophage antibiotic peptide MCP-1 , SMCP-1A , mast cell protease 1A

GENE ID SPEZIES
748205 Pan troglodytes
24770 Rattus norvegicus
6347 Homo sapiens
20296 Mus musculus
281043 Bos taurus
100009130 Oryctolagus cuniculus
397422 Sus scrofa
403981 Canis lupus familiaris
100135494 Cavia porcellus
100034136 Equus caballus
100172740 Pongo abelii
101120093 Ovis aries
574138 Macaca mulatta
100009115 Oryctolagus cuniculus
443546 Ovis aries
Ausgewählte Anbieter für Chemokine (C-C Motif) Ligand 2 Proteine (CCL2)
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