PVRL4 Proteine (PVRL4)

Bezeichnung:
Poliovirus Receptor-Related 4 Proteine (PVRL4)
Auf www.antikoerper-online.de finden Sie aktuell 18 Poliovirus Receptor-Related 4 (PVRL4) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PVRL4 Antikörper (73) und PVRL4 Kits (6) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 100 PVRL4 Produkte verfügbar.
Synonyme:
1200017F15Rik, EDSS1, LNIR, nectin-4, PRR4, PVRL4, RGD1559826, si:ch211-155e24.1
alle Proteine anzeigen Gen GeneID UniProt
PVRL4 71740 Q8R007
Ratte PVRL4 PVRL4 498281  
PVRL4 81607 Q96NY8

Weitere Synonyme anzeigen

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Weitere Proteine zu PVRL4 Interaktionspartnern

Mouse (Murine) Poliovirus Receptor-Related 4 (PVRL4) Interaktionspartner

  1. nectin-4 serves as a stimulatory co-receptor for the prolactin receptor (zeige PRLR Proteine) by regulating the feedback inhibition of SOCS1 (zeige SOCS1 Proteine) in the JAK2 (zeige JAK2 Proteine)-STAT5a (zeige STAT5A Proteine) signaling pathway

  2. Novel type of cell adhesion apparatus is mediated by Nectin-1 (zeige PVRL1 Proteine) and Nectin-4. It's implicated in prolactin receptor (zeige PRLR Proteine) signaling for mammary gland development.

  3. Pvrl1 (zeige PVRL1 Proteine) is a bona fide target gene of the transcription factor p63 (zeige CKAP4 Proteine), whereas Pvrl4 regulation is linked to epidermal differentiation and is under Irf6 (zeige IRF6 Proteine)

  4. Mouse PVRL4 functions less efficiently as a receptor for measles virus than the human homologue.

  5. Ectodermal dysplasia-syndactyly syndrome is the second known "nectinopathy" caused by mutations in a nectin (zeige PVRL1 Proteine) adhesion molecule (zeige NCAM1 Proteine).

Human Poliovirus Receptor-Related 4 (PVRL4) Interaktionspartner

  1. High Nectin-4 expression is associated with neoplasms.

  2. We show that Measles virus gains entry into MCF7, DLD (zeige DLD Proteine)-1, and HTB-20 cancer cells through a PVRL4-mediated macropinocytosis pathway and identified the typical cellular GTPase (zeige RACGAP1 Proteine) and kinase involved.

  3. nectin-4 serves as a stimulatory co-receptor for the prolactin receptor (zeige PRLR Proteine) by regulating the feedback inhibition of SOCS1 (zeige SOCS1 Proteine) in the JAK2 (zeige JAK2 Proteine)-STAT5a (zeige STAT5A Proteine) signaling pathway

  4. Nectin-4 is both a new promising prognostic biomarker and specific therapeutic target for Triple-negative breast cancers

  5. ADAM17 (zeige ADAM17 Proteine) and ADAM10 (zeige ADAM10 Proteine) cleave Nectin-4 and release soluble Nectin-4 (sN4).

  6. The data presented in this study suggested that nectin-4 may be a therapeutic target for systemic lupus erythematous through affecting the cell apoptosis

  7. Nectin-4 is critical for gallbladder cancer cell progression via PI3K/AKT pathway activation of Rac1.

  8. Nectin-4 expression, when compared with control group, was higher in endometriotic lesions of patients having ovarian endometriosis and peritoneal endometriosis. This difference was significant in the endometrium of patients having endometriosis.

  9. Transformation of breast cancer cells is dependent on PVRL4.

  10. Nectin-4 is a significant prognostic predictor, and may play a critical role in pancreatic cancer. Nectin-4 may be novel therapeutic target for pancreatic cancer.

PVRL4 Protein Überblick

Protein Überblick

This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.

Alternative names and synonyms associated with PVRL4

  • poliovirus receptor-related 4 (PVRL4)
  • poliovirus receptor-related 4 (pvrl4)
  • poliovirus receptor-related 4 (LOC100348580)
  • poliovirus receptor-related 4 (Pvrl4)
  • 1200017F15Rik Protein
  • EDSS1 Protein
  • LNIR Protein
  • nectin-4 Protein
  • PRR4 Protein
  • PVRL4 Protein
  • RGD1559826 Protein
  • si:ch211-155e24.1 Protein

Bezeichner auf Proteinebene für PVRL4

poliovirus receptor-related 4 , poliovirus receptor-related protein 4-like , ig superfamily receptor LNIR , nectin 4 , nectin-4 , poliovirus receptor-related protein 4 , Ig superfamily receptor LNIR

GENE ID SPEZIES
609931 Canis lupus familiaris
794920 Danio rerio
100032730 Monodelphis domestica
100066309 Equus caballus
100348580 Oryctolagus cuniculus
100435072 Pongo abelii
71740 Mus musculus
498281 Rattus norvegicus
81607 Homo sapiens
507718 Bos taurus
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