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CYR61 (zeige CYR61 ELISA Kits) negatively regulates the nucleoside transporters hENT1 and hCNT3 (zeige SLC28A3 ELISA Kits) in pancreatic ductal adenocarcinoma.
Chronic inhibition of ENT1 or by genetic removal of ENT1 enhanced the survival of R6/2 mice. Collectively, adenosine homeostasis and ENT1 expression are altered in Huntington's disease (HD). The inhibition of ENT1 can enhance extracellular adenosine level and be a potential therapeutic approach for treating HD.
Combined expression analyses of hENT1, TS, and DPD (zeige DPYD ELISA Kits) may predict long-term outcomes in patients with borderline resectable pancreatic cancer after neoadjuvant chemoradiotherapy
studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y12R that contribute to its effective inhibition of platelet activation.
These findings suggest that ENT1 is regulated via receptor-dependent calcium-linked pathways resulting in an alteration of purine flux, which may modulate purinergic signaling and influence NA drug efficacy.
SLC29A1 rs760370 and KLF12 (zeige KLF12 ELISA Kits) rs9543524 SNPs are associated with treatment induced thrombocytopenia in chronic hepatitis C patients treated with PEGIFN2b/ribavirin/combination.
interaction of Met(33) (involved in dipyridamole binding) with BCR-ABL (zeige ABL1 ELISA Kits) inhibitors and reduced interaction with M33A mutant hENT1.
Authors clearly demonstrate that ribavirin uptake in primary human hepatocytes is variable and correlates with ENT1 expression.
A pro-apoptotic effect of verapamil was observed in L3.6pl cells, but not in L3.6plGres cells, which was linked to their differential expression of P-gp (zeige ABCB4 ELISA Kits) and equilibrative nucleoside transporter-1 (ENT-1).
Human ENT1 proteins exist as two sub-populations, and cytidine pre-treatment leads to the internalization of one population.
These pathways are consistent with previously reported behavioral and biochemical phenotypes that typify mice lacking ENT1. Moreover, we validated decreased expression of the SNARE (zeige VTI1B ELISA Kits) complex protein VAMP1 (synaptobrevin-1 (zeige VAMP1 ELISA Kits)) in the dHip as well as decreased expression of pro-dynorphin (PDYN (zeige PDYN ELISA Kits)), neuroendocrine convertase (PCSK1 (zeige PCSK1 ELISA Kits)), and Leu-Enkephalin (dynorphin-A (zeige PDYN ELISA Kits)) in the nucleus accumbens
results establish Augustine as a new blood group (zeige DARC ELISA Kits) system and place SLC29A1 as a new candidate gene for idiopathic disorders characterized with ectopic calcification/mineralization.
Findings demonstrate that ENT1 regulates GFAP (zeige GFAP ELISA Kits) expression and possibly astrocyte function
ENT1-regulated adenosine signaling plays an essential role in lumbar spine and femur bone density
findings implicate ENT1 in liver protection from ischemia and reperfusion injury and suggest ENT inhibitors may be of benefit in the prevention or treatment of ischemic liver injury
This is the first report of a role for ENT1 in regulating the calcification of soft tissues. ENT1(-/-) mice may be a useful model for investigating pathogenesis and evaluating therapeutics for the prevention of mineralization in DISH and related disord
It was shown that the responsiveness of kidney tubules and glomeruli is significantly attenuated in the absence of ENT1, leading to changes of extracellular adenosine levels in the juxtaglomerular apparatus interstitium.
This study demonstrated that the A2AR (zeige ADORA2A ELISA Kits) antagonist ZM241385 dampened protein kinase A activity-mediated signaling in the DMS and promoted excessive ethanol drinking in ENT1(+/+) mice
Perfusions without sodium drastically reduced the intestinal loss of ribavirin in both wild-type and Ent1(-/-) mice.
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
equilibrative NBMPR-sensitive nucleoside transporter
, equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter
, equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter
, equilibrative nucleoside transporter 1
, nucleoside transporter, es-type
, solute carrier family 29 (nucleoside transporters), member 1
, solute carrier family 29 member 1
, solute carrier family 29, member 1
, NBMPR-sensitive equilibrative nucleoside transporter
, equilibrative nucleoside transporter 1 variant delta 11