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Human RPS6 Protein expressed in Wheat germ - ABIN1318818
Lee, Mustafa, Hudes, Kruger: Hydroxychloroquine Destabilizes Phospho-S6 in Human Renal Carcinoma Cells. in PLoS ONE 2015
Dual PI3K (zeige PIK3CA Proteine)/mTOR (zeige FRAP1 Proteine) inhibition represents an effective therapeutic strategy in uterine leiomyosarcoma, and p-S6(S240) expression is a potential predictive biomarker for response to treatment.
this study unveils an unprecedented correlation of mTOR (zeige FRAP1 Proteine) activation with improved clinical outcome in patients with laryngeal carcinomas and uncovers the potential of p-S6 expression as a good prognostic biomarker and an inverse predictor of lymph node and distant metastases.
the aggregation of rpS6 at the nucleolus correlates to the phasing of cell cycle, beginning to concentrate in the nucleolus at later S phase and disaggregate at M phase.
Data suggest ribosomal protein S6 (rpS6) as tumor marker for renal cell carcinoma (zeige MOK Proteine).
Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer
p-rpS6 is a robust post-treatment indicator of HER2 (zeige ERBB2 Proteine) pathway-targeted therapy resistance
Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K (zeige RPS6KB1 Proteine) and RPS6 activation.
Tanshinone IIA inhibits HIF-1alpha (zeige HIF1A Proteine) and VEGF (zeige VEGFA Proteine) expression in breast cancer cells via mTOR (zeige FRAP1 Proteine)/p70S6K (zeige RPS6KB1 Proteine)/RPS6/4E-BP1 (zeige EIF4EBP1 Proteine) signaling pathway.
The expression levels of phospho-mTOR (zeige FRAP1 Proteine) and phospho-S6RP may be potential predictive biomarkers for efficacy of everolimus in patients with metastatic renal cell carcinoma (zeige MOK Proteine).
we report that phosphorylation of ribosomal protein S6 is greatly increased in BRCA1 deficient cells resistant to PARP inhibition
in adult cardiac myocytes 4-hydroxy-trans-2-nonenal stimulates protein synthesis by activation of mTORC1-p70S6K (zeige RPS6KB1 Proteine)-RPS6 signaling
rpS6 phosphorylation facilitates the increase in cyclin D1 (zeige CCND1 Proteine) and decrease in cyclin E1 (zeige CCNE1 Proteine) that underlie the hypertrophic nature of uninephrectomy-induced kidney growth.
The mTORC1 effectors, RPS6 and eIF4E, play distinct roles and are both necessary for AKT/Ras hepatocarcinogenesis.
Activation of mTORC2 (zeige CRTC2 Proteine) plays a pivotal role in cardioprotection, and Rps6 is a convergence point of cardioprotective signaling, providing positive feedback regulation of mTORC2 (zeige CRTC2 Proteine)/Akt (zeige AKT1 Proteine) signaling.
Data indicate that the mTOR (zeige FRAP1 Proteine) activity evaluated by the phosphorylation status of ribosomal protein S6, and phospho-S6 (pS6) levels was found declined shortly after rapamycin treatment in both cortex and hippocampus.
Downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6.
regulatory protein (zeige TGFB1 Proteine) S6 phosphorylation is controlled by Akt (zeige AKT1 Proteine), downstream to PI-3K and upstream to mTOR (zeige FRAP1 Proteine) in an IL2 (zeige IL2 Proteine)-mediated signal transduction pathway
Rps6 phosphorylation is a determinant of cell size and glucose homeostasis.
the phosphorylation of Tyr (zeige TYR Proteine)(1077) on LepRb (zeige LEPR Proteine) during receptor activation, substantiate the hypothalamic regulation of STAT5 (zeige STAT5A Proteine) and S6 by leptin (zeige LEP Proteine), and define the alternate LepRb (zeige LEPR Proteine) signaling pathways
rpS6, especially in its unphosphorylated form, is a selective mediator of TRAIL-induced apoptosis
molecular network including eIF1AX (zeige EIF1AY Proteine), RPS7 (zeige RPS7 Proteine), and 14-3-3gamma (zeige YWHAG Proteine) regulates protein translation and cell proliferation in BMECs.
Arg, Leu, and Gln act coordinately to stimulate proliferation of pTr cells through activation of the MTOR (zeige FRAP1 Proteine)-RPS6K-RPS6-EIF4EBP1 (zeige EIF4EBP1 Proteine) signal transduction pathway.
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
40S ribosomal protein S6
, phosphoprotein NP33
, ribosomal Protein, Small subunit (28.1 kD) (rps-6)
, ribosomal protein S6 a
, hemocytes enlarged
, lethal(1)aberrant immune response
, lethal-(1)-haemocytes enlarged
, minute (1) 7BC
, ribosomal protein S6