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cap1 regulates cortical actin distribution specifically in the anterior mesendoderm of the zebrafish gastrula.
The requirement of Cap1 for a cellular apical constriction step suggests a conservation of gene function for a cell biological event critical to many developmental processes.
CAP1 (zeige PRSS8 ELISA Kits) expression is markedly increased in human glioma and that downregulation of CAP1 (zeige PRSS8 ELISA Kits) in tumors may serve as a treatment for glioma patients.
our results indicated that CAP1 (zeige PRSS8 ELISA Kits) participated in the molecular pathological process of glioma
a high expression of CAP1 (zeige PRSS8 ELISA Kits) is involved in the pathogenesis of EOC, and that the downregulation of CAP1 (zeige PRSS8 ELISA Kits) in tumor cells may be a therapeutic target for the treatment of patients with EOC.
This study demonstrated an inverse relationship between CAP1 (zeige PRSS8 ELISA Kits) and MMP-9 (zeige MMP9 ELISA Kits) expression, high expression of MMP-9 (zeige MMP9 ELISA Kits) and low expression of CAP1 (zeige PRSS8 ELISA Kits) in those with chronic obstructive pulmonary disease compared with the non-chronic obstructive pulmonary disease group.
CAP1 (zeige PRSS8 ELISA Kits) is involved in the brain metastasis in non-small cell lung cancer.CAP1 overexpression is associated with poor prognosis in non-small cell lung cancer patients.
Overexpression of CAP1 (zeige PRSS8 ELISA Kits) in monocytes enhanced the resistin (zeige RETN ELISA Kits)-induced increased activity of the cAMP-dependent signaling.
results indicate that upregulated expression of CAP1 (zeige PRSS8 ELISA Kits) might contribute heavily to the metastasis of hepatocellular carcinoma.
Overexpression of CAP1 (zeige PRSS8 ELISA Kits) is associated with breast carcinoma.
CAP1 (zeige PRSS8 ELISA Kits) might be a potential molecular targeted therapy for surgery and immune treatment.
overexpression of CAP1 (zeige PRSS8 ELISA Kits) in lung cancer cells, particularly at the metastatic stage, may have significant clinical implications as a diagnostic/prognostic factor for lung cancer.
Studies in colonic T84 cell monolayers revealed that barrier disruption by the colitis-associated Th2-type cytokines, IL-4 (zeige IL4 ELISA Kits) and IL-13 (zeige IL13 ELISA Kits), down-regulates matriptase (zeige ST14 ELISA Kits) as well as prostasin (zeige PRSS8 ELISA Kits) through phosphorylation of the transcriptional regulator STAT6 (zeige STAT6 ELISA Kits)
a proteolysis-dependent function of activated prostasin (zeige PRSS8 ELISA Kits) in hair follicles, dependent on zymogen conversion by matriptase (zeige ST14 ELISA Kits).
The claudin-4 (zeige CLDN4 ELISA Kits)-mediated chloride conductance can be regulated endogenously by a protease-channel-activating protease 1 (cap1 (zeige PRSS8 ELISA Kits)).
Phosphorylation regulates CAP1 function through association with cofilin and actin in order to control the actin cytoskeleton.
HAI-1 (zeige SPINT1 ELISA Kits) regulates the activity of activated matriptase (zeige ST14 ELISA Kits), whereas HAI-2 (zeige SPINT2 ELISA Kits) has an essential role in regulating prostasin (zeige PRSS8 ELISA Kits)-dependent matriptase (zeige ST14 ELISA Kits) zymogen activation.
a novel inhibitory interaction between CAP1/Prss8 (zeige PRSS8 ELISA Kits) and nexin-1 (zeige SERPINE2 ELISA Kits), opening the search for specific CAP1/Prss8 (zeige PRSS8 ELISA Kits) antagonists that are independent of its catalytic activity
Data indicate that liver-specific serine protease (zeige F2 ELISA Kits) prostasin (PRSS8 (zeige PRSS8 ELISA Kits)) knockout (LKO) mice develop insulin (zeige INS ELISA Kits) resistance associated with the increase in hepatic Toll-like receptor 4 (TLR4 (zeige TLR4 ELISA Kits)).
Data indicate that serine protease (zeige F2 ELISA Kits) prostasin (CAP1/PRSS8 (zeige PRSS8 ELISA Kits)) supports terminal epidermal differentiation through a non-catalytic mechanism.
CAP1 depletion also led to changes in cofilin phosphorylation and localization as well as activation of focal adhesion kinase (FAK) and enhanced cell spreading.
study provides evidence that catalyzing nucleotide exchange on actin monomers via the beta-sheet domain is the most highly conserved function of CAPs (zeige CAPS ELISA Kits) from mammals to apicomplexan parasites.
Bovine herpesvirus 1 infection stimulates caspase 1 (zeige CASP1 ELISA Kits) activity.
The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants have been identified.
adenylyl cyclase-associated protein 1
, CAP, adenylate cyclase-associated protein 1
, CAP, adenylate cyclase-associated protein 1 (yeast)
, adenylyl cyclase-associated protein
, Adenylyl cyclase-associated protein 1
, CAP 1
, adenylyl cyclase-associated CAP protein homolog 1 iae
, adenylyl cyclase-associated CAP protein, yeast homolog 1
, cyclase-associated protein homologue
, channel activating protease 1
, channel-activating protease 1
, serine protease 8