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The results presented here show the major role of LAMP-2 (zeige LAMP2 ELISA Kits) in caveolin traffic and membrane repair and consequently in T. cruzi invasion.
Here, we identify lamellar inclusions as the subcellular site of lipid accumulation in neurons, we uncover a vicious cycle of cholesterol synthesis and accretion, which may cause gradual neurodegeneration, and we reveal how beta-cyclodextrin, a potential therapeutic drug, reverts these changes. Our study provides new mechanistic insight in NPC (zeige NPC1 ELISA Kits) disease and uncovers new targets for therapeutic approaches.
we demonstrate that galectin-3 (zeige LGALS3 ELISA Kits) induces MMP9 (zeige MMP9 ELISA Kits) expression via p38 MAP-kinase (zeige MAPK14 ELISA Kits) pathway. LAMP1 was demonstrated to serve as one of the key mediators of galectin-3 (zeige LGALS3 ELISA Kits)-induced MMP9 (zeige MMP9 ELISA Kits) expression via p38 MAPK (zeige MAPK14 ELISA Kits) pathway
Although surface LAMP1 promotes interactions with organ ECM (zeige MMRN1 ELISA Kits) and BM, carbohydrates on LAMP1 play a decisive role in dictating lung metastasis.
The results thus for the first time provide direct evidence that cell surface LAMP1 facilitates lung metastasis by providing ligands for galectin-3 (zeige LGALS3 ELISA Kits) which has been shown to be expressed in highest amounts on lungs and constitutively on its vascular endothelium.
Caveolin-1 (zeige CAV1 ELISA Kits) associated adenovirus entry into human corneal cells.
study has shown that Lassa virus entry requires a pH-regulated engagement of alpha-DG and LAMP1 both of which need to be glycosylated
CD107a/LAMP-1 has a role in the protection of NK cells from degranulation-associated suicide
LAMP proteins retain TAPL (zeige ABCB9 ELISA Kits) on the limiting membrane of endosomes and prevent its sorting to intraluminal vesicles.
a novel mechanism showing how Salmonella acquires LAMP1 through a SipC-Syntaxin6-mediated interaction probably to stabilize their niche in macrophages
The authors show here that human LAMP1 and LAMP2 (zeige LAMP2 ELISA Kits) bind cholesterol in a manner that buries the cholesterol 3beta-hydroxyl group; they also bind tightly to NPC1 (zeige NPC1 ELISA Kits) and NPC2 (zeige NPC2 ELISA Kits) proteins that export cholesterol from lysosomes.
downregulation of FUT1 (zeige FUT1 ELISA Kits), which leads to the perinuclear localization of LAMP-1 and 2, is correlated with increased rate of autophagic flux by decreasing mTOR (zeige FRAP1 ELISA Kits) signaling and increasing autolysosome formation.
the assembly modes of LAMP-1 and LAMP-2 (zeige LAMP2 ELISA Kits) are different, which may underlie their distinct functions
Overexpression of LAMP1 was observed in prostate cancer (PCa (zeige FLVCR1 ELISA Kits)) and castration-resistant prostate cancer clinical specimens. Moreover, downstream pathways were identified using si-LAMP1-transfected cells. The discovery of tumor-suppressive miR320a-mediated pathways may provide important insights into the potential mechanisms of PCa (zeige FLVCR1 ELISA Kits) metastasis.
The data implied that high LAMP1 expression is associated with unfavourable prognosis in laryngeal squamous cell carcinoma patients, and LAMP1 may be identified as a novel prognostic biomarker
The data support a viral entry mechanism dependent on binding to the lysosome-resident receptor LAMP1 and further dissociation of the membrane-distal GP1 subunits.
A unique triad of histidines of Lassa Virus GP1 (zeige GTPBP1 ELISA Kits) forms a binding site for host LAMP1.
The LAMP-1 had preferential localization in the high density secondary lysosomes where endogenous human LAMP-1 was enriched. In contrast, a major portion of I382L was located in a low density fraction.
Downregulation of miR (zeige MLXIP ELISA Kits)-184 was consistent with significantly lower levels of LAMP-1
Human miR (zeige MLXIP ELISA Kits)-373 is silenced by histone modification in lung cancer cells and is a negative regulator of the mesenchymal phenotype through downstream IRAK2 (zeige IRAK2 ELISA Kits) and LAMP1 target genes.
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis.
120 kDa lysosomal membrane glycoprotein
, CD107 antigen-like family member A
, LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEIN 1 PRECURSOR (LAMP-1) (LGP-A) (LGP-120) (CD107A) (P2B)
, Lamp I
, lysosomal membrane glycoprotein 1
, lysosomal membrane glycoprotein A
, lysosome-associated membrane glycoprotein 1
, lysosome-associated membrane protein 1
, Lysosomal associated membrane protein 1 (120 kDa)
, chromaffin granule-associated membrane glycoprotein IIA
, glycoprotein IIa
, lysosome membrane glycoprotein LEP100
, Lysosome-associated membrane glycoprotein 1