PSMB8 Antikörper

Produktnummer ABIN969371

Produktdetails anti-PSMB8 Antikörper

Target: PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PSMB8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human PSMB8 expressed in E. coli.

Klon: 1A5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-PSMB8 Antikörper (ABIN969371)

Camarena, Aquino-Galvez, Falfán-Valencia, Sánchez, Montaño, Ramos, Juárez, García-de-Alba, Granados, Selman: "PSMB8 (LMP7) but not PSMB9 (LMP2) gene polymorphisms are associated to pigeon breeder's hypersensitivity pneumonitis." in: Respiratory medicine, Vol. 104, Issue 6, pp. 889-94, (2010) (PubMed).

Mehta, Jordanova, Corver, van Wezel, Uh, Kenter, Jan Fleuren: "Single nucleotide polymorphisms in antigen processing machinery component ERAP1 significantly associate with clinical outcome in cervical carcinoma." in: Genes, chromosomes & cancer, Vol. 48, Issue 5, pp. 410-8, (2009) (PubMed).

Details zu PSMB8

Target: PSMB8 (Proteasome (Prosome, Macropain) Subunit, beta Type, 8 (Large Multifunctional Peptidase 7) (PSMB8))

Andere Bezeichnung: PSMB8 (PSMB8 Produkte)

Synonyme: ALDD antikoerper, D6S216 antikoerper, D6S216E antikoerper, JMP antikoerper, LMP7 antikoerper, NKJO antikoerper, PSMB5i antikoerper, RING10 antikoerper, ATP6V0D2 antikoerper, lmp7 antikoerper, prosome antikoerper, macropain antikoerper, Lmp-7 antikoerper, Lmp7 antikoerper, Ring10 antikoerper, proteasome subunit beta 8 antikoerper, proteasome subunit beta 8A antikoerper, proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) antikoerper, PSMB8 antikoerper, psmb8a antikoerper, Psmb8 antikoerper

Hintergrund:

Description: The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified, both isoforms are processed to yield the same mature subunit.

Aliases: JMP, LMP7, D6S216, PSMB5i, RING10, D6S216E, MGC1491

Molekulargewicht: 30 kDa

Gen-ID: 5696

HGNC: 5696

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA