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AKAP1 Antikörper (AA 66-212)

AKAP1 Reaktivität: Human, Ratte WB, IHC, IF, IP Wirt: Maus Monoclonal 6-AKAP149 unconjugated
Produktnummer ABIN968136
  • Target Alle AKAP1 Antikörper anzeigen
    AKAP1 (A Kinase (PRKA) Anchor Protein 1 (AKAP1))
    Bindungsspezifität
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 66-212
    Reaktivität
    • 28
    • 2
    • 1
    Human, Ratte
    Wirt
    • 25
    • 3
    Maus
    Klonalität
    • 28
    Monoklonal
    Konjugat
    • 21
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser AKAP1 Antikörper ist unkonjugiert
    Applikation
    • 18
    • 11
    • 10
    • 8
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    Kreuzreaktivität
    Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human AKAP149 aa. 66-212
    Klon
    6-AKAP149
    Isotyp
    IgG1
    Top Product
    Discover our top product AKAP1 Primärantikörper
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    Related Products: ABIN968535, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Schillace, Andrews, Liberty, Davey, Carr: "Identification and characterization of myeloid translocation gene 16b as a novel a kinase anchoring protein in T lymphocytes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 4, pp. 1590-9, (2002) (PubMed).

    Tanji, Yamamoto, Yorioka, Kohno, Kikuchi, Kikuchi: "A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 36955-61, (2002) (PubMed).

    Steen, Collas: "Mistargeting of B-type lamins at the end of mitosis: implications on cell survival and regulation of lamins A/C expression." in: The Journal of cell biology, Vol. 153, Issue 3, pp. 621-6, (2001) (PubMed).

    DellAcqua, Scott: "Protein kinase A anchoring." in: The Journal of biological chemistry, Vol. 272, Issue 20, pp. 12881-4, (1997) (PubMed).

    Trendelenburg, Hummel, Riecken, Hanski: "Molecular characterization of AKAP149, a novel A kinase anchor protein with a KH domain." in: Biochemical and biophysical research communications, Vol. 225, Issue 1, pp. 313-9, (1996) (PubMed).

  • Target
    AKAP1 (A Kinase (PRKA) Anchor Protein 1 (AKAP1))
    Andere Bezeichnung
    AKAP149 (AKAP1 Produkte)
    Synonyme
    AKAP1 antikoerper, akap1 antikoerper, fa08b04 antikoerper, wu:fa08b04 antikoerper, AKAP antikoerper, AKAP121 antikoerper, AKAP149 antikoerper, AKAP84 antikoerper, D-AKAP1 antikoerper, PPP1R43 antikoerper, PRKA1 antikoerper, SAKAP84 antikoerper, TDRD17 antikoerper, Akap antikoerper, C76494 antikoerper, C81186 antikoerper, DAKAP1 antikoerper, S-AKAP84 antikoerper, Akap84 antikoerper, A-kinase anchoring protein 1 antikoerper, A kinase (PRKA) anchor protein 1b antikoerper, A kinase (PRKA) anchor protein 1 antikoerper, AKAP1 antikoerper, akap1b antikoerper, akap1 antikoerper, Akap1 antikoerper
    Hintergrund
    The targeting of protein kinases and phosphatases to cellular compartments in a timely manner may provide specificity in signal transduction events. For instance, attachment of type II cAMP-dependent Protein Kinase (PKA) to the cytoskeleton occurs through the binding of the regulatory subunit (RII) to microtubule associated-protein 2. Several proteins, such as microtubule-associated protein 2, have been identified as PKA type I/II anchoring proteins and form a family named AKAP (A-Kinase Anchor Proteins). AKAP149 is a protein of 903 amino acids. It has a PKA [RII] binding site at amino acids 355-376 preceded by a leucine zipper domain. AKAP149 mRNA has been reported to be expressed ubiquitously, with the highest levels in prostate and small intestine. AKAP149 contains a KH domain characteristic of RNA-binding proteins. Thus, AKAP149 is a PKA [RII] anchoring protein that may target this kinase to sites of RNA processing for regulation of RNA binding protein activity. This antibody is routinely tested by western blot analysis.
    Molekulargewicht
    149 kDa
    Pathways
    Synaptic Membrane
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