CD36 Molecule (thrombospondin Receptor) (CD36) Antikörper

Antigen: CD36 Molecule (thrombospondin Receptor) (CD36)

Synonyme: FAT, GP4, GP3B, GPIV, CHDS7, PASIV, SCARB3

Klonalität: Monoklonal (TR9)

Wirt: Maus

Reaktivität: Human

Applikation: Durchflusszytometrie (FACS)

Produktnummer: ABIN94082

Produktbeschreibung

Weitere Bezeichnung: CD36

Immunogen: Platelets

Format: Purified

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: TR9

Beschreibung: CD36 (fatty acid translocase, FAT) is an 88 kDa ditopic glycosylated protein that belongs tothe class B family of scavenger receptors. CD36 is expressed by most resting marginal zoneB cells but not by follicular and B1 B cells, and it is rapidly induced on Follicular B cells invitro upon TLR and CD40 stimulation. CD36 does not affect the development of B cells, butmodulates both primary and secondary antibody response. Similarly to glucose transporterGLUT4, CD36 is translocated from intracellular pools to the plasma membrane following cellstimulation by insulin. In mouse, CD36 is responsible for gustatory perception of long-chainfatty acids.

Spezifität: The antibody TR9 reacts with CD36 (GPIIIb), a 85 kDa integral membrane glycoproteinexpressed on platelets, macrophages, endothelial cells, early erythroid cells andmegakaryocytes. The antibody TR9 cross-blocks binding of FITC-labeled standard antibodyOKM5.Anti-CD36 antibodies inhibit adhesive functions (e.g. adherence of infected erythrocytes totarget cells).

Anwendungen

Konzentration: 1 mg/ml

Reinheit: > 95% (by SDS-PAGE)

Reinigung: Purified from ascites by precipitation methods and ion exchange chromatography.

Buffer: 20 mM Tris/HCl with 15 mM sodium azide, approx. pH 7.4

Lagerung: Store at 2-8 o C. Do not use after expiration date stamped on vial label. For long-term storage aliquot and store at -20 o C. Avoid freeze/thaw cycles.

Forschungsgebiet: Krebs, Artherosklerose, Hämopoetische Vorläufer, Hämatopoetische Stammzellen, CD Antigene, Oberflächenrezeptoren der Immunzellen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Bilder

Surface staining of human platelets with anti-CD36 (TR9) FITC.