TLR4 Antikörper (N-Term)

Produktnummer ABIN920639

Der Kaninchen Polyklonal anti-TLR4 Antikörper wird verwendet zum Nachweis von TLR4 in Proben von Human. Er wurde validiert für WB und ICC.

Kurzübersicht für TLR4 Antikörper (N-Term) (ABIN920639)

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunocytochemistry (ICC)

Produktdetails anti-TLR4 Antikörper

Bindungsspezifität: N-Term

Produktmerkmale: Positive Control: Located in the membrane and highly expressed in placenta, spleen and peripheral blood leukocytes. Detected in monocytes, macrophages, dendritic cells and several types of T-cells.

Aufreinigung: Antigen Immunoaffinity purified

Immunogen: Rabbit polyclonal TLR4 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of TLR4.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: use at 2-5 µg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu TLR4

Target: TLR4 (Toll-Like Receptor 4 (TLR4))

Hintergrund: Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Studies with TLR4 deficient mice indicate that the main ligand for TLR is lipopolysaccharide. Consequently, these mice also showed increased susceptibility to Gram- negative sepsis. Synonyms:

Molekulargewicht: 95 kDa

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteine