The antibody detects endogenous level of total Ring1A protein.
Aufreinigung
Affinity purified
Immunogen
Peptide sequence around AA 35-39 ( I-A-V-S-P) derived from Human Ring1A. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
RING1A antikoerper, RNF1 antikoerper, Ring1A antikoerper, bap-1 antikoerper, bap1 antikoerper, ding antikoerper, hipi3 antikoerper, ring1a antikoerper, ring1b antikoerper, ring2 antikoerper, rnf1 antikoerper, rnf2-a antikoerper, ring1 antikoerper, ring1b-B antikoerper, rnf2-b antikoerper, ring finger protein 1 antikoerper, ring finger protein 1 S homeolog antikoerper, ring finger protein 1 L homeolog antikoerper, RING1 antikoerper, Ring1 antikoerper, ring1.S antikoerper, ring1.L antikoerper
Hintergrund
Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.