TAZ Antikörper (AA 386-390)
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- Target Alle TAZ Antikörper anzeigen
- TAZ (Tafazzin (TAZ))
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Bindungsspezifität
- AA 386-390
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser TAZ Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- The antibody detects endogenous level of total TAZ protein.
- Aufreinigung
- Affinity purified
- Immunogen
- Peptide sequence around AA 386-390 (V-E-S-A-L) derived from Human TAZ. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
- Top Product
- Discover our top product TAZ Primärantikörper
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- Applikationshinweise
- Western blotting: 1:500-1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 1 mg/mL
- Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Target
- TAZ (Tafazzin (TAZ))
- Andere Bezeichnung
- TAZ (TAZ Produkte)
- Synonyme
- wu:fb39f12 antikoerper, zgc:91803 antikoerper, MGC54019 antikoerper, TAZ antikoerper, taz antikoerper, GB11956 antikoerper, Afu2g13960 antikoerper, BTHS antikoerper, CMD3A antikoerper, EFE antikoerper, EFE2 antikoerper, G4.5 antikoerper, LVNCX antikoerper, Taz1 antikoerper, 5031411C02Rik antikoerper, 9130012G04Rik antikoerper, AW107266 antikoerper, AW552613 antikoerper, tafazzin antikoerper, tafazzin L homeolog antikoerper, tafazzin homolog antikoerper, TAZ antikoerper, taz antikoerper, taz.L antikoerper, LOC550948 antikoerper, AFUA_2G13960 antikoerper, AOR_1_318014 antikoerper, Tsp_06712 antikoerper, Taz antikoerper
- Hintergrund
- Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.
- Molekulargewicht
- 49 kDa
- Gen-ID
- 25937
- NCBI Accession
- NP_001161
- UniProt
- Q9GZV5
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