MST1 Antikörper (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)) (AA 400-450)

Details for Product anti-MST1 Antibody No. ABIN747308, Anbieter: Anmelden zum Anzeigen
Antigen
  • D3F15S2
  • DNF15S2
  • HGFL
  • MSP
  • NF15S2
  • D3F15S2h
  • D9H3F15S2
  • DNF15S2h
  • Hgfl
  • E2F2
  • HGF1/MSP
  • macrophage stimulating 1 (hepatocyte growth factor-like)
  • Macrophage stimulating 1 (hepatocyte growth factor-like)
  • MST1
  • Mst1
Epitop
AA 400-450
22
15
14
7
6
6
5
4
3
3
3
2
2
2
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
92
22
18
3
2
2
2
2
1
Wirt
Kaninchen
73
26
Klonalität
Polyklonal
Konjugat
Dieser MST1 Antikörper ist unkonjugiert
6
6
5
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
79
46
33
18
12
12
5
2
2
2
2
Optionen
Hersteller
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Immunogen KLH conjugated synthetic peptide derived from human MST1
Isotyp IgG
Reinigung Purified by Protein A.
Andere Bezeichnung Mst1 (MST1 Antibody Abstract)
Hintergrund

Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes.

Subcellular location: Cytoplasm, Nucleus

Synonyms: KRS2, MST1, YSK3, TIIAC, Serine/threonine-protein kinase 4, Mammalian STE20-like protein kinase 1, MST-1, STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2, STK4

Gen-ID 6789
UniProt Q13043
Forschungsgebiet Cancer, Innate Immunity, Signaling
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months
Bilder des Herstellers
ELISA image for anti-MST1 Antikörper (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)) (AA 400-450) (ABIN747308) Antigen: 0.2 µg/100 µL Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:...
Immunohistochemistry (IHC) image for anti-MST1 Antikörper (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)) (AA 400-450) (ABIN747308) Formalin-fixed and paraffin embedded mouse embryo labeled with Anti-CMST1 Polyclonal ...
Immunohistochemistry (IHC) image for anti-MST1 Antikörper (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)) (AA 400-450) (ABIN747308) Formalin-fixed and paraffin embedded rat brain labeled with Anti-MST1 Polyclonal Anti...
Western Blotting (WB) image for anti-MST1 Antikörper (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)) (AA 400-450) (ABIN747308) Mouse liver lysates probed with Rabbit Anti-MST1 Polyclonal Antibody, Unconjugated a...
Western Blotting (WB) image for anti-MST1 Antikörper (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)) (AA 400-450) (ABIN747308) Mouse liver lysates probed with Rabbit Anti-MST1 Polyclonal Antibody, Unconjugated a...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MST1 Antikörper (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)) (AA 400-450) (ABIN747308) Formalin-fixed and paraffin embedded human prostate labeled with Anti-MST1 Polyclonal...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-MST1 Antikörper (Macrophage Stimulating 1 (Hepatocyte Growth Factor-Like)) (AA 400-450) (ABIN747308) Formalin-fixed and paraffin embedded human laryngeal labeled with Anti-MST1 Polyclona...