Interferon, gamma-Inducible Protein 16 (IFI16) Antikörper (Cy5)

Antigen: Interferon, gamma-Inducible Protein 16 (IFI16)

Synonyme: PYHIN2, IFNGIP1, MGC9466, p204, Ifi16, IFI16, DKFZp468E1111

Klonalität: Polyklonal

Wirt: Kaninchen

Reaktivität: Human

Konjugat: Cy5

Applikation: Durchflusszytometrie (FACS), Immunfluoreszenz (IF)

Produktnummer: ABIN687041

Produktbeschreibung

Weitere Bezeichnung: IFI16

Immunogen: Polyclonal antibodies are produced by immunizing animals with synthetic peptide derived from human IFI16 N-terminus

Format: Lyophilized

Wiederherstellung: Reconstitute with 100ul sterille distilled water. After reconstitution, stock concentration=1ug/1ul, preservatives included (BSA=10ug/ul, Sodium azide=0.1%)

Isotyp: IgG

Beschreibung: Synonym: Gamma-interferon-inducible protein Ifi16, Interferon-inducible myeloid differentiation transcriptional activator, A730048F03, D3, D3cDNA, Ifi-d3, IFI16, IFI16B, IFI204, IFI205, Ifi205a, Ifi205b, IFNGIP1, MGC9466, Mnda, p204, PYHIN2.

Spezifität: Excitation / Emission Wavelengths: 650nm/670nm

Molekulargewicht: 86kDa

Kommentare:

Interferon (IFN) Inducible 16 (IFI16) protein belongs to a family of HIN 200 human and mouse proteins. IFI16 is a nuclear protein comtaining regulatory domains such as DNA binding domain

transcriptional regulatory domain and DAPIN/PAAD domain. IFI16 has three isotypes A

B

and C (85-95 kDa)

which arise as a result of mRNA alternative splicing. All are phosphorylated on serine and threonine residues and can homo and heterodimerize. Expression is restricted to the nuclei of hematopoietic cells

fibroblasts and epithelial cells. IFI16 expression in hematopoietic cells of myeloid lineage is tightly regulated and highly induced in the differentiation and proliferation of the cell. Due to its localization in the nucleus

regulation of protein expression

and ability to bind DNA

it is assumed that IFI16 has a role in transcription regulation of cell differentiation. In addition

it was found that IFI16 can act as a transcriptional repressor and is involved in regulation and activation of p53 in cancer cells.

Anwendungen

Applikationshinweise: Flow-Cyt (1:50-200), IF (1:50-200)

Konzentration: 1mg/1ml

Reinigung: Antibodies are purified by protein A and peptide affinity chromatography.

Buffer: 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

Lagerung: Ship at room temperature. Store at -20°C

Forschungsgebiet: Transkriptionsfaktoren, DNS/RNS, Apoptose/Nekrose

Beschränkungen: Nur für Forschungszwecke einsetzbar