APP Antikörper (Amyloid beta (A4) Precursor Protein) (AA 333-362)

Details for Product anti-APP Antibody No. ABIN657612, Anbieter: Anmelden zum Anzeigen
Antigen
  • APP
  • APP-like
  • APPL
  • Abeta
  • BcDNA:GH04413
  • CG7727
  • Dmel\\CG7727
  • EG:65F1.5
  • appl
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • AAA
  • ABETA
  • ABPP
  • AD1
  • APPI
  • CTFgamma
  • CVAP
  • PN-II
  • PN2
  • Abpp
  • Adap
  • Ag
  • Cvap
  • E030013M08Rik
  • betaApp
  • app
  • wu:fj34d10
  • wu:fk65e12
  • zgc:85740
  • beta amyloid protein precursor-like
  • amyloid beta (A4) precursor protein
  • amyloid beta (A4) precursor protein a
  • beta amyloid protein precursor
  • Appl
  • APP
  • app
  • App
  • appa
  • LOC100009546
Alternativen
anti-Human APP Antikörper für Dot Blot
Epitop
AA 333-362, Center
101
95
68
37
30
25
24
19
17
16
15
15
14
14
12
9
7
7
7
7
6
6
6
5
5
5
5
5
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
875
364
351
40
27
21
19
18
15
13
12
10
7
7
4
4
4
3
2
2
1
Wirt
Kaninchen
630
229
45
7
2
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser APP Antikörper ist unkonjugiert
49
39
39
16
14
13
13
13
13
12
12
12
12
12
12
8
8
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
623
365
273
157
149
120
83
56
41
34
18
14
10
9
8
3
2
2
1
1
1
Optionen
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Bilder

Immunogen This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 333-362 AA from the Central region of human APP.
Klon RB33592
Isotyp Ig
Spezifität This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 332-362 amino acids from the Central region of human APP.
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification.
Andere Bezeichnung APP (APP Antibody Abstract)
Hintergrund This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Synonyms: Amyloid beta A4 protein,APP,A4, AD1
Molekulargewicht 79kd Isoform. 86943 DA
Gen-ID 351
NCBI Accession NP_001129601, NP_958816, NP_001129602, NP_000475
UniProt P05067
Forschungsgebiet Apoptosis/Necrosis, Phospho-specific antibodies, Cell Signaling, Cell Structure, Protein Modifications, Neurology
Pathways Caspase Kaskade in der Apoptose, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
Applikationshinweise WB = 1:1000, IF = 1:10-50, IHC (p) = 1:10-50
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung APP Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-APP Antikörper (Amyloid beta (A4) Precursor Protein) (AA 333-362) (ABIN657612) APP Antibody (Center) (ABIN657612) western blot analysis in 293 cell line lysates (35...
Allgemeine Veröffentlichungen Singh, Park, Bae, Yun, Bae, Park, Kim: "MEGF10 functions as a receptor for the uptake of amyloid-β." in: FEBS letters, Vol. 584, Issue 18, pp. 3936-42, 2010 (PubMed).

Crews, Adame, Patrick, Delaney, Pham, Rockenstein, Hansen, Masliah: "Increased BMP6 levels in the brains of Alzheimer's disease patients and APP transgenic mice are accompanied by impaired neurogenesis." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 37, pp. 12252-62, 2010 (PubMed).