This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogen
This CYP8B1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 471-501 amino acids from the C-terminal region of human CYP8B1.
MGC64456 antikoerper, CYP8B antikoerper, CP8B antikoerper, CYP12 antikoerper, cytochrome P450 family 8 subfamily B member 1 antikoerper, cytochrome P450 family 8 subfamily B member 1 S homeolog antikoerper, cytochrome P450, family 8, subfamily B, polypeptide 1 antikoerper, cytochrome P450, family 8, subfamily b, polypeptide 1 antikoerper, Cyp8b1 antikoerper, cyp8b1.S antikoerper, CYP8B1 antikoerper
Hintergrund
CYP8B1 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these two steroids determines the relative amounts of cholic acid and chenodeoxycholic acid both of which are secreted in the bile and affect the solubility of cholesterol. This gene is unique among the cytochrome P450 genes in that it is intronless.