ZBP1 Antikörper (C-Term)

Produktnummer ABIN783819

Produktdetails anti-ZBP1 Antikörper

Target: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to ZBP1.

Aufreinigung: Affinity chromatography

Immunogen: 18 amino acid peptide from near the carboxy terminus of human ZBP1.

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % sodium azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu ZBP1

Target: ZBP1 (Z-DNA Binding Protein 1 (ZBP1))

Andere Bezeichnung: ZBP1 (ZBP1 Produkte)

Synonyme: C20orf183 antikoerper, DAI antikoerper, DLM-1 antikoerper, DLM1 antikoerper, 2010010H03Rik antikoerper, Dai antikoerper, Dlm1 antikoerper, mZaDLM antikoerper, ZBP1 antikoerper, Z-DNA binding protein 1 antikoerper, ZBP1 antikoerper, Zbp1 antikoerper

Hintergrund: Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Za domain which binds specifically to left-handed Z-DNA and Z-RNA. ZBP1 was initially identified as a novel gene that was up-regulated in activated macrophages in mice bearing ascites tumors, suggesting that is may play a role in processes such as host response in neoplasia. More recent reports indicate that the cytosolic ZBP1 has can act like the toll-like receptor TLR9 by detecting cytosolic double-stranded (ds) DNA and trigger induction of type I interferon and other innate immune responses. It is thought that the binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as the IRF3 transcription factor and the serine/threonine kinase TBK1 (also known as NAK). Multiple isoforms of ZBP1 are known to exist.Synonyms: C20orf183, DLM1, Z-DNA-binding protein 1

Gen-ID: 81030

NCBI Accession: NP_001153889

UniProt: Q9H171