SP110 Antikörper (C-Term)

Produktnummer ABIN783558

Produktdetails anti-SP110 Antikörper

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SP110 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects SP110 at C-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the carboxy terminus of the human IPR1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu SP110

Target: SP110 (SP110 Nuclear Body Protein (SP110))

Andere Bezeichnung: SP110 (SP110 Produkte)

Synonyme: SP110 antikoerper, IFI41 antikoerper, IFI75 antikoerper, IPR1 antikoerper, VODI antikoerper, 5031415C07Rik antikoerper, 52kDa antikoerper, 5830484A20Rik antikoerper, ENSMUSG00000075603 antikoerper, Ifi75 antikoerper, Ipr1 antikoerper, SP110 nuclear body protein antikoerper, Sp110 nuclear body protein antikoerper, SP110 antikoerper, Sp110 antikoerper

Hintergrund: Susceptibility to tuberculosis (TB) in mice has recently been attributed to the IPR1 gene. IPR1 is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. SP110 is the closest homolog of the IPR1 protein in humans. The IPR1/Sp110 gene product might play a role in integrating signals generated by intracellular pathogens with mechanisms controlling innate immunity, cell death, and pathogenesis. IPR1/Sp110 is up-regulated after infection with M. tuberculosis and required by Anaplasma phagocytophilum for infection of human promyelocytic cells. Defects in Sp110 are a cause of severely impaired resistance to infection by M. tuberculosis.Synonyms: FLJ22835, IPR1, SP-110, SP110 nuclear body protein, Speckled 110 kD, VODI

Gen-ID: 3431

NCBI Accession: NP_001171944

UniProt: Q9HB58