SERPINI2 Antikörper (Internal Region)

Produktnummer ABIN374538

Produktdetails anti-SERPINI2 Antikörper

Target: SERPINI2 (serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 (SERPINI2))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SERPINI2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody is expected to recognize both reported isoforms (NP_006208.1 and NP_001012303.1).

Kreuzreaktivität (Details): Species reactivity (expected):Mouse, Rat, Canine and (Dog).
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence C-KGDWKQKFRKEDTQ, from the internal region of the protein sequence. Genename: SERPINI2

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Antibody detection limit dilution: 1/64000. Western Blot: 0.3-1 μg/mL. Approx 40 kDa band observed in Human Pancreas lysates (calculated MW of 46.0 kDaaccording to NP_006208.1 and 47.0 kDa and NP_001012303.1). Immunohistochemistry on Paraffin Sections: 3 μg/mL. In paraffin embedded Human Pancreas, shows cytoplasmic staining of acinar cels and ofrare cells in the islets of Langerhans.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preserative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SERPINI2

Target: SERPINI2 (serpin Peptidase Inhibitor, Clade I (Pancpin), Member 2 (SERPINI2))

Andere Bezeichnung: SERPINI2 (SERPINI2 Produkte)

Synonyme: Spi14 antikoerper, MEPI antikoerper, PANCPIN antikoerper, PI14 antikoerper, TSA2004 antikoerper, serpin family I member 2 antikoerper, serpin peptidase inhibitor, clade I (pancpin), member 2 L homeolog antikoerper, serpin peptidase inhibitor, clade I (pancpin), member 2 antikoerper, serine (or cysteine) peptidase inhibitor, clade I, member 2 antikoerper, SERPINI2 antikoerper, serpini2.L antikoerper, Serpini2 antikoerper

Hintergrund: MEP1 is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. It may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.Synonyms: MEPI, Myoepithelium-derived serine protease inhibitor, PI14, Pancpin, Protease inhibitor 14, TSA2004

Gen-ID: 5276

NCBI Accession: NP_006208

UniProt: O75830