GGCX Antikörper (C-Term)

Produktnummer ABIN452673

Produktdetails anti-GGCX Antikörper

Target: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Bindungsspezifität: C-Term

Reaktivität: Human, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser GGCX Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: GGCX antibody AP09596PU-N is expected to recognize both isoforms (NP_000812.2 and NP_001135741.1).

Kreuzreaktivität (Details): Species reactivity (expected):Canine (Dog).
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide.

Immunogen: Peptide with sequence C-PPESNPDPVHSE, from the C-Terminus of the protein sequence according to NP_000812.2 and NP_001135741.1.

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: GGCX Antibody Detection limit dilution 1/32000. Western blot: 0.3-1 μg/mL. Approx 85 kDa band observed in Human Muscle lysates(calculated MW of 85 kDa according to NP_000812.2).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu GGCX

Target: GGCX (gamma-Glutamyl Carboxylase (GGCX))

Andere Bezeichnung: GGCX (GGCX Produkte)

Synonyme: GGCX antikoerper, cb751 antikoerper, si:ch1073-230p18.3 antikoerper, zgc:158736 antikoerper, ggcx antikoerper, GGC antikoerper, vkcfd1 antikoerper, CG13927 antikoerper, DgammaC antikoerper, Dmel\\CG13927 antikoerper, dGC antikoerper, dgammaC antikoerper, gammaC antikoerper, VKCFD1 antikoerper, gamma-glutamyl carboxylase antikoerper, gamma-glutamyl carboxylase L homeolog antikoerper, GGCX antikoerper, ggcx antikoerper, GC antikoerper, sce5891 antikoerper, ggcx.L antikoerper, Ggcx antikoerper

Hintergrund: Gamma-glutamyl carboxylase GGCX is an enzyme which catalyzes the posttranslational modification of vitamin K-dependent protein. Many of these vitamin K-dependent proteins are involved in coagulation so the function of the encoded enzyme is essential for hemostasis. Mutations in this gene are associated with vitamin K-dependent coagulation defect and PXE-like disorder with multiple coagulation factor deficiency. GGCX accomplishes the posttranslational modification required for the activity of all of the vitamin K-dependent proteins (Wu et al., 1991 [PubMed 1749935]). These include some of the blood coagulation and anticoagulation proteins as well as bone gamma-carboxyglutamic acid (Gla) protein (BGLAP, MIM 112260) and bone matrix protein (MGP, MIM 154870).Synonyms: GC, Gamma-glutamyl carboxylase, Vitamin K gamma glutamyl carboxylase, Vitamin K-dependent gamma-carboxylase

Gen-ID: 2677

NCBI Accession: NP_000812

UniProt: P38435

Pathways: SARS-CoV-2 Protein Interaktom