TCEB3 Antikörper

Produktnummer ABIN498446

Produktdetails anti-TCEB3 Antikörper

Target: TCEB3 (Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) (TCEB3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TCEB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects endogenous levels of Elongin A1 protein. (region surrounding Arg129)

Kreuzreaktivität (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Aufreinigung: Affinity chromatography

Reinheit: > 95 % by SDS-PAGE

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1,0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu TCEB3

Target: TCEB3 (Transcription Elongation Factor B (SIII), Polypeptide 3 (110kDa, Elongin A) (TCEB3))

Andere Bezeichnung: TCEB3 (TCEB3 Produkte)

Synonyme: CG6755 antikoerper, Dmel\\CG6755 antikoerper, Elo-A antikoerper, dEloA antikoerper, tceb3a antikoerper, zgc:56638 antikoerper, wu:fw66g10 antikoerper, TCEB3 antikoerper, 110kDa antikoerper, AA408125 antikoerper, Tceb3a antikoerper, El antikoerper, EloA antikoerper, SIII antikoerper, SIII p110 antikoerper, TCEB3A antikoerper, Elongin A antikoerper, transcription elongation factor B polypeptide 3 antikoerper, elongin A antikoerper, calcium binding and coiled-coil domain 1b antikoerper, elongin A S homeolog antikoerper, transcription elongation factor B subunit 3 antikoerper, EloA antikoerper, LOC413407 antikoerper, eloa antikoerper, calcoco1b antikoerper, ELOA antikoerper, eloa.S antikoerper, Eloa antikoerper, TCEB3 antikoerper

Hintergrund: Individuals harboring germline mutations in the tumor suppressor gene von Hippel-Lindau (VHL) exhibit an increased susceptibility to a variety of tumors including renal carcinom,a hemangio-blastoma of the central nervous system and pheochromo-cytoma. The Elongin (SIII) complex has been identified as the functional target of the VHL protein. Elongin (SIII) is a heterotrimer composed of a transcriptional active subunit designated Elongin A and two regulatory subunits designated Elongin B and Elongin C. VHL functions by binding to the Elongin B and C subunits, inhibiting the transcriptional efficacy of the Elongin (SIII) complex. The VHL protein migrates with an apparent molecular weight of 38 kDa. The Elongin A subunit is 773 amino acids in length and has an apparent molecular weight of 110 kD,a while Elongin B and C are 18 kDa and 15 kDa proteins, respectively.Synonyms: EloA, Elongin 110 kDa subunit, Elongin A, Elongin-A, RNA polymerase II transcription factor SIII subunit A1, Transcription elongation factor B polypeptide 3

Molekulargewicht: approx. 78 kDa

Gen-ID: 6924

NCBI Accession: NP_003189

UniProt: Q14241