PIP4K2A Antikörper (C-Term)

Produktnummer ABIN392598

Produktdetails anti-PIP4K2A Antikörper

Target: PIP4K2A (Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, alpha (PIP4K2A))

Bindungsspezifität: AA 303-335, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PIP4K2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Homologie: M, Pig, Rat

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PIP4K2 Alpha (PIP4K2A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 303-335 amino acids from the C-terminal region of human PIP4K2 Alpha (PIP4K2A).

Klon: RB1741

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Referenzen für anti-PIP4K2A Antikörper (ABIN392598)

Jones, Foulger, Keune, Bultsma, Divecha: "PtdIns5P is an oxidative stress-induced second messenger that regulates PKB activation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 4, pp. 1644-56, (2013) (PubMed).

Keune, Jones, Bultsma, Sommer, Zhou, Lu, Divecha: "Regulation of phosphatidylinositol-5-phosphate signaling by Pin1 determines sensitivity to oxidative stress." in: Science signaling, Vol. 5, Issue 252, pp. ra86, (2012) (PubMed).

Huang, Anderson, Cao, Wiechmann, Rajala: "Light-induced tyrosine phosphorylation of rod outer segment membrane proteins regulate the translocation, membrane binding and activation of type II ? phosphatidylinositol-5-phosphate 4-kinase." in: Neurochemical research, Vol. 36, Issue 4, pp. 627-35, (2011) (PubMed).

Bultsma, Keune, Divecha: "PIP4Kbeta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4Kalpha." in: The Biochemical journal, Vol. 430, Issue 2, pp. 223-35, (2010) (PubMed).

Wilcox, Hinchliffe: "Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2alpha." in: FEBS letters, Vol. 582, Issue 9, pp. 1391-4, (2008) (PubMed).

Details zu PIP4K2A

Target: PIP4K2A (Phosphatidylinositol-5-Phosphate 4-Kinase, Type II, alpha (PIP4K2A))

Andere Bezeichnung: PIP5K2 Alpha (PIP5K2A) (PIP4K2A Produkte)

Synonyme: PI5P4KA antikoerper, PIP5K2A antikoerper, PIP5KII-alpha antikoerper, PIP5KIIA antikoerper, PIPK antikoerper, AW742916 antikoerper, Pip5k2a antikoerper, pipk antikoerper, pi5p4ka antikoerper, pip5k2a antikoerper, pip5kiia antikoerper, pip4k2a antikoerper, zgc:194746 antikoerper, zgc:194777 antikoerper, phosphatidylinositol-5-phosphate 4-kinase type 2 alpha antikoerper, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha antikoerper, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha S homeolog antikoerper, phosphatidylinositol-5-phosphate 4-kinase, type II, alpha a antikoerper, PIP4K2A antikoerper, Pip4k2a antikoerper, pip4k2a.S antikoerper, pip4k2a antikoerper, pip4k2aa antikoerper

Hintergrund: Phosphatidylinositol-4,5-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. TPIP5K2A is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. The protein is a member of the phosphatidylinositol-4-phosphate 5-kinase family.

Molekulargewicht: 46225

Gen-ID: 5305

NCBI Accession: NP_005019

UniProt: P48426

Pathways: Inositol Metabolic Process