HGS Antikörper (N-Term)

Produktnummer ABIN388936

Produktdetails anti-HGS Antikörper

Target: HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Bindungsspezifität: AA 256-286, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser HGS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This HGS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 256-286 amino acids from the N-terminal region of human HGS.

Klon: RB4400

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu HGS

Target: HGS (Hepatocyte Growth Factor-Regulated tyrosine Kinase Substrate (HGS))

Andere Bezeichnung: HGS (HGS Produkte)

Synonyme: HRS antikoerper, Hrs antikoerper, fi34f05 antikoerper, zgc:63492 antikoerper, wu:fi34f05 antikoerper, Hgr antikoerper, ZFYVE8 antikoerper, CG2903 antikoerper, Dmel\\CG2903 antikoerper, HRS-2 antikoerper, Vps27 antikoerper, hrs antikoerper, l(2)23AB5 antikoerper, l(2)23Ad antikoerper, l(2)23Ad(Hrs) antikoerper, vps27 antikoerper, hgs antikoerper, hepatocyte growth factor-regulated tyrosine kinase substrate antikoerper, HGF-regulated tyrosine kinase substrate antikoerper, Hepatocyte growth factor regulated tyrosine kinase substrate antikoerper, hepatocyte growth factor-regulated tyrosine kinase substrate L homeolog antikoerper, HGS antikoerper, Hgs antikoerper, hgs antikoerper, Hrs antikoerper, hgs.L antikoerper

Hintergrund: HGS is involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. It could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. HGS may concentrate ubiquitinated receptors within clathrin-coated regions. It is involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM. This complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. HGS may contribute to the efficient recruitment of SMADs to the activin receptor complex.

Molekulargewicht: 86192

Gen-ID: 9146

NCBI Accession: NP_004703

UniProt: O14964

Pathways: EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Synaptic Vesicle Exocytosis, EGFR Downregulation