FOXC1 Antikörper (C-Term)
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- Target Alle FOXC1 Antikörper anzeigen
- FOXC1 (Forkhead Box C1 (FOXC1))
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Bindungsspezifität
- C-Term
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Reaktivität
- Human, Maus, Zebrafisch (Danio rerio)
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Wirt
- Ziege
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Klonalität
- Polyklonal
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Konjugat
- Dieser FOXC1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Chromatin Immunoprecipitation (ChIP), Enzyme Immunoassay (EIA)
- Sequenz
- RTSGAFVYDC SKF
- Spezifität
- This antibody detects FOXC1 / FKHL7 / FREAC3 at C-term.
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human, Mouse, Zebrafish.
- Aufreinigung
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
- Immunogen
- Peptide from C-Terminus of the protein sequence according to NP_001444.2. Genename: FOXC1
- Top Product
- Discover our top product FOXC1 Primärantikörper
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- Applikationshinweise
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Peptide ELISA: Limit dilution 1: 32000. Western blot: 0.5-1.5 μg/mL. Approx 55 kDa band observed in Human Bone Marrow lysates(calculated MW of 56.5 kDa according to NP_001444.1). Immunohistochemistry: 3 μg/mL. In paraffin embedded Human Kidney shows nuclearstaining of some cells in the glomeruli.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C.
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FOXC1 Regulates Expression of Prostaglandin Receptors Leading to an Attenuated Response to Latanoprost." in: Investigative ophthalmology & visual science, Vol. 59, Issue 6, pp. 2548-2554, (2019) (PubMed).
: "Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation." in: The Journal of clinical investigation, Vol. 126, Issue 7, pp. 2437-51, (2017) (PubMed).
: "Dysfunction of the stress-responsive FOXC1 transcription factor contributes to the earlier-onset glaucoma observed in Axenfeld-Rieger syndrome patients." in: Cell death & disease, Vol. 5, pp. e1069, (2014) (PubMed).
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FOXC1 Regulates Expression of Prostaglandin Receptors Leading to an Attenuated Response to Latanoprost." in: Investigative ophthalmology & visual science, Vol. 59, Issue 6, pp. 2548-2554, (2019) (PubMed).
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- Target
- FOXC1 (Forkhead Box C1 (FOXC1))
- Andere Bezeichnung
- FOXC1 / FKHL7 / FREAC3 (FOXC1 Produkte)
- Synonyme
- ARA antikoerper, FKHL7 antikoerper, FREAC-3 antikoerper, FREAC3 antikoerper, IGDA antikoerper, IHG1 antikoerper, IRID1 antikoerper, RIEG3 antikoerper, FoxC1 antikoerper, fkhl7 antikoerper, freac-3 antikoerper, freac3 antikoerper, igda antikoerper, ihg1 antikoerper, irid1 antikoerper, rieg3 antikoerper, xfd-11 antikoerper, ara antikoerper, FOXC1 antikoerper, foxc1 antikoerper, Fkh1 antikoerper, Mf1 antikoerper, Mf4 antikoerper, ch antikoerper, fkh-1 antikoerper, frkhda antikoerper, CFKH-1 antikoerper, XFD-11 antikoerper, foxc1.2 antikoerper, id:ibd5079 antikoerper, forkhead box C1 antikoerper, forkhead box C1 S homeolog antikoerper, forkhead box C1 L homeolog antikoerper, Forkhead box protein C1 antikoerper, winged helix transcription factor XFD-11 antikoerper, forkhead box C1b antikoerper, FOXC1 antikoerper, Foxc1 antikoerper, foxc1.S antikoerper, foxc1 antikoerper, foxc1.L antikoerper, foxc1-A antikoerper, foxc1b antikoerper
- Hintergrund
- FOXC1 belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined, however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.Synonyms: FREAC-3, Forkhead box protein C1, Forkhead-related protein FKHL7, Forkhead-related transcription factor 3
- Molekulargewicht
- 56.8kDa (NP_001444.1).
- Gen-ID
- 2296
- NCBI Accession
- NP_001444
- UniProt
- Q12948
- Pathways
- Chromatin Binding, Glycosaminoglycan Metabolic Process
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