FOXP3 Antikörper (C-Term)

Produktnummer ABIN374156

Produktdetails anti-FOXP3 Antikörper

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Bindungsspezifität: C-Term

Reaktivität: Human, Schwein, Hund

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser FOXP3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequenz: SQRPSRCSNP TPGP

Spezifität: This antibody is expected to recognize both reported isoforms (NP_054728.2 and NP_001107849.1).

Kreuzreaktivität (Details): Species reactivity (expected):Canine (Dog) and Pig.
Species reactivity (tested):Human.

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide from C-Terminus of the protein sequence according to NP_054728.2, NP_001107849.1. Genename: FOXP3

Anwendungsinformationen

Applikationshinweise: Peptide ELISA: Limit Dilution: 1/16000. Immunohistochemistry: 0.3-1 μg/mL. In paraffin embedded Human Tonsil, stains nuclei ofsome cells in the interfollicular area.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu FOXP3

Target: FOXP3 (Forkhead Box P3 (FOXP3))

Andere Bezeichnung: FOXP3 (FOXP3 Produkte)

Synonyme: foxp3 antikoerper, FOXP3 antikoerper, AIID antikoerper, DIETER antikoerper, IPEX antikoerper, PIDX antikoerper, XPID antikoerper, JM2 antikoerper, scurfin antikoerper, sf antikoerper, RGD1562112 antikoerper, forkhead box P3 antikoerper, forkhead box P3a antikoerper, forkhead box P3 L homeolog antikoerper, FOXP3 antikoerper, foxp3a antikoerper, foxp3 antikoerper, foxp3.L antikoerper, Foxp3 antikoerper

Hintergrund: FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.Synonyms: Forkhead box protein P3, IPEX, JM2, Scurfin

Gen-ID: 50943

NCBI Accession: NP_054728

UniProt: Q9BZS1

Pathways: Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation