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DRAM Antikörper (C-Term)

DRAM1 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN372924
  • Target Alle DRAM (DRAM1) Antikörper anzeigen
    DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))
    Bindungsspezifität
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 17
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 17
    Kaninchen
    Klonalität
    • 17
    Polyklonal
    Konjugat
    • 13
    • 2
    • 1
    • 1
    Dieser DRAM Antikörper ist unkonjugiert
    Applikation
    • 12
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Spezifität
    This antibody recognizes Damage-regulated Autophagy Modulator (DRAM).
    Kreuzreaktivität (Details)
    Species reactivity (expected):Mouse and Rat.
    Species reactivity (tested):Human.
    Aufreinigung
    Immunoaffinity Chromatography.
    Immunogen
    Synthetic peptide - KLH conjugated corresponding to a 16 amino acids peptide from near the carboxy terminus of Human DRAM.
    Isotyp
    IgG
    Top Product
    Discover our top product DRAM1 Primärantikörper
  • Applikationshinweise
    ELISA. Western blot: 0.5-1.0 μg/mL. Immunohistochemistry on Frozen Sections: 2.5 μg/mL. Immunohistochemistry on Paraffin Sections: 3 μg/mL. This antibody was validated for use in immunohistochemistry on a panel of 21formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigenretrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides wereincubated with biotinylated secondary antibody LS-D1, followed by alkalinephosphatase-streptavidin and chromogen.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
  • Target
    DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))
    Andere Bezeichnung
    DRAM1 (DRAM1 Produkte)
    Synonyme
    DRAM1 antikoerper, DRAM antikoerper, 1200002N14Rik antikoerper, Dram antikoerper, dram antikoerper, DNA damage regulated autophagy modulator 1 antikoerper, DNA-damage regulated autophagy modulator 1 antikoerper, DNA damage regulated autophagy modulator 1 L homeolog antikoerper, DRAM1 antikoerper, Dram1 antikoerper, dram1.L antikoerper
    Hintergrund
    Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.Synonyms: DNA damage regulated autophagy modulator protein 1, DRAM, DRAM-1, FLJ11259
    Gen-ID
    55332
    NCBI Accession
    NP_060840
    UniProt
    Q8N682
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