TLX1 Antikörper (AA 300-330)
-
- Target Alle TLX1 Antikörper anzeigen
- TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))
-
Bindungsspezifität
- AA 300-330
-
Reaktivität
- Maus, Human, Ratte
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- Dieser TLX1 Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody recognizes Homeobox Protein Hox-11 (TLX1).
- Kreuzreaktivität (Details)
-
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - Aufreinigung
- Protein G Chromatography.
- Immunogen
- Synthetic peptide corresponding to a portion of amino acids 300-330 of human HOX11.
- Isotyp
- IgG
- Top Product
- Discover our top product TLX1 Primärantikörper
-
-
- Applikationshinweise
-
Immunohistochemistry on Paraffin Sections: 5 μg/mL. Western blot: 1-3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 0.5 mg/mL
- Buffer
- PBS containing 0.2 % Gelatin as stabilizer and 0.05 % Sodium Azide as preservative.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.
-
- Target
- TLX1 (T-Cell Leukemia Homeobox 1 (TLX1))
- Andere Bezeichnung
- TLX1 (TLX1 Produkte)
- Synonyme
- Hox-11 antikoerper, Hox11 antikoerper, HOX11 antikoerper, TCL3 antikoerper, XHox11 antikoerper, XHox11L2 antikoerper, hox11 antikoerper, tlx1-a antikoerper, TLX-1 antikoerper, RGD1563655 antikoerper, SI:dZ46P4.1 antikoerper, Tlx-1 antikoerper, ztlx-1 antikoerper, T cell leukemia, homeobox 1 antikoerper, T-cell leukemia homeobox 1 antikoerper, T-cell leukemia homeobox 1 L homeolog antikoerper, T-cell leukemia, homeobox 1 antikoerper, Tlx1 antikoerper, TLX1 antikoerper, tlx1.L antikoerper, tlx1 antikoerper
- Hintergrund
- HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35,q24) or t(10:14)(q24,qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.Synonyms: HOX11, Hox-11, T-cell leukemia homeobox protein 1, T-cell leukemia/lymphoma protein 3, TCL-3, TCL3, TLX-1
- Gen-ID
- 3195
- NCBI Accession
- NP_005512
- UniProt
- P31314
-