ZMIZ1 Antikörper (C-Term)

Produktnummer ABIN358726

Produktdetails anti-ZMIZ1 Antikörper

Target: ZMIZ1 (Zinc Finger, MIZ-Type Containing 1 (ZMIZ1))

Bindungsspezifität: AA 596-626, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ZMIZ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to RAI17.

Aufreinigung: Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: KLH conjugated synthetic peptide between 596~626 amino acids from the C-terminal region of Human RAI17

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu ZMIZ1

Target: ZMIZ1 (Zinc Finger, MIZ-Type Containing 1 (ZMIZ1))

Andere Bezeichnung: ZMIZ1 / RAI17 (ZMIZ1 Produkte)

Synonyme: miz antikoerper, rai17 antikoerper, zimz1 antikoerper, zimp10 antikoerper, hzimp10 antikoerper, MIZ antikoerper, RAI17 antikoerper, TRAFIP10 antikoerper, ZIMP10 antikoerper, hZIMP10 antikoerper, BC065120 antikoerper, E330020C23 antikoerper, ENSMUSG00000072684 antikoerper, Gm10397 antikoerper, I920194n01 antikoerper, Rai17 antikoerper, Zimp10 antikoerper, wu:fb80e10 antikoerper, zgc:175159 antikoerper, zmiz1 antikoerper, zinc finger MIZ-type containing 1 antikoerper, zinc finger, MIZ-type containing 1 antikoerper, zinc finger, MIZ-type containing 1a antikoerper, ZMIZ1 antikoerper, zmiz1 antikoerper, Zmiz1 antikoerper, zmiz1a antikoerper

Hintergrund: Retinoic acid plays a critical role in development, cellular growth, and differentiation and induces the expression of a variety of genes. RAI17 expression is induced by retinoic acid and is predominantly expressed in heart, brain and ovaries. Within brain, highest expression is in amygdala. The deduced 1,067-amino acid protein contains an MSX-interacting zinc finger (MIZ) domain, a nuclear localization signal sequence, and 2 proline-rich regions. A strong intrinsic transactivation domain is identified in the C-terminal proline-rich region. RAI17 expression is detected in various cancer cell lines. RAI17 colocalizes with endogenous androgen receptor (AR) in the nuclei of prostate epithelial cells from human tissue samples. In human prostate cancer cells, RAI17 increases the transcriptional activity of AR. Studies using sumoylation-deficient AR mutants suggest that the increase of AR activity by RAI17 is dependent upon receptor sumoylation.Synonyms: KIAA1224, PIAS-like protein Zimp10, Retinoic acid-induced protein 17, ZIMP10, Zinc finger MIZ domain-containing protein 1

Gen-ID: 57178, 9606

UniProt: Q9ULJ6