Synaptosomal-Associated Protein, 25kDa (SNAP25) Antikörper

Antigen: Synaptosomal-Associated Protein, 25kDa (SNAP25)

Synonyme: RIC4, SEC9, SNAP, RIC-4, SNAP-25, FLJ23079, bA416N4.2, dJ1068F16.2, ric4, sec9, ric-4, snap-25, MGC68863, SNAP25, MGC139754, DKFZp459B0611, DKFZp459G0410, sp, Bdr, SNAP-25B, MGC105414, snap25

Klonalität: Polyklonal

Wirt: Schaf

Reaktivität: Human

Applikation: Immunhistochemie (IHC), Western Blot (WB)

Produktnummer: ABIN350902

Produktbeschreibung

Weitere Bezeichnung: Synaptosomal associated protein 25 (SNAP-25,SNAP25)

Swiss-Prot: P60880

Immunogen: A synthetic peptidefrom human Synaptosomal associated protein 25 (SNAP-25, SNAP25, SEC9) conjugated to an immunogenic carrier protein was used as the immunogen.

Format: Lyophilized

Isotyp: IgG  (Passende Sekundärantikörper)

Beschreibung: FUNCTION: t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. SUBUNIT: Part of the SNARE core complex containingSNAP25, VAMP2 and STX1A. This complex binds CPLX1. Interacts with TRIM9, RIMS1,SNAP25BP and HGS. Binds STXBP6. Found in a ternary complex with STX1A and VAMP8. Found in a complex containing SYT1, SV2B and syntaxin-1. SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Cell junction, synapse, synaptosome. Note: Membrane association requires palmitoylation. TISSUE SPECIFICITY: Neurons of the neocortex, hippocampus, piriform cortex, anterior thalamic nuclei, pontine nuclei, and granule cells of the cerebellum. Also known as:SNAP-25, Synaptosomal-associated 25 kDa protein,SNAP25, RIC4, SEC9,SNAP, RIC-4, Super protein, SUP.

Spezifität: Appears to be specific for SNAP-25.

Anwendungen

Applikationshinweise: IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Reinheit: IgG

Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Zhao, Hashida, Takahashi et al.: "Cloning and sequence analysis of the human SNAP25 cDNA." in: Gene, Vol. 145, Issue 2, pp. 313-4, 1994 (PubMed).

Bark, Wilson: "Human cDNA clones encoding two different isoforms of the nerve terminal protein SNAP-25." in: Gene, Vol. 139, Issue 2, pp. 291-2, 1994 (PubMed).

Jagadish, Fernandez, Hewish et al.: "Insulin-responsive tissues contain the core complex protein SNAP-25 (synaptosomal-associated protein 25) A and B isoforms in addition to syntaxin 4 and synaptobrevins 1 and 2." in: The Biochemical journal, Vol. 317 ( Pt 3), pp. 945-54, 1996 (PubMed).

Deloukas, Matthews, Ashurst et al.: "The DNA sequence and comparative analysis of human chromosome 20." in: Nature, Vol. 414, Issue 6866, pp. 865-71, 2002 (PubMed).

Chen, Tomchick, Kovrigin et al.: "Three-dimensional structure of the complexin/SNARE complex." in: Neuron, Vol. 33, Issue 3, pp. 397-409, 2002 (PubMed).