CD14 Molecule (CD14) Antikörper

Antigen: CD14 Molecule (CD14)

Synonyme: CD14

Klonalität: Monoklonal (BiG 4)

Wirt: Maus

Reaktivität: Human

Applikation: Durchflusszytometrie (FACS), Funktionale Studien (Func), ELISA

Produktnummer: ABIN343171

Produktbeschreibung

Weitere Bezeichnung: CD14

Immunogen: Monocytes of humans and different animals as well as immunoaffinity purified soluble CD14

Format: Lyophilized

Isotyp: IgG1  (Passende Sekundärantikörper)

Klon: BiG 4

Beschreibung: BiG 4 represents an excellent marker for CD14. The CD14 glycoprotein, gp 55, is present on most monocytic and macrophages like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is also observed on granulocytes and activated or transformed B-cells. Furthermore CD14 is present in a soluble form in human serum, urine and other body fluids. The CD14 molecule has been reported to be a receptor for endotoxin.

Anwendungen

Applikationshinweise: Suitable for immunostaining of CD14positive cells ,ELISA, CD14 inhibition studies. Not useful for Western Blot. No significant inhibition of LPS-binding to human CD14 transfected CHO cells

Konzentration: 0.8mg/ml

Reinigung: Protein G purified

Buffer: 0.1 mg without NaN3

Lagerung: long time storage at -20°C or

Forschungsgebiet: Stammzellen, Angeborene Immunität, Hämopoetische Vorläufer, Hämatopoetische Stammzellen, CD Antigene, Oberflächenrezeptoren der Immunzellen , Apoptose/Nekrose, Immunologie, Inflammation

Beschränkungen: Nur für Forschungszwecke einsetzbar

Publikationen

Publikationen: Stelter, Bernheiden, Menzel et al.: "Mutation of amino acids 39-44 of human CD14 abrogates binding of lipopolysaccharide and Escherichia coli." in: European journal of biochemistry / FEBS, Vol. 243, Issue 01. Feb, pp. 100-9, 1997 (PubMed).