Factor VIII Antikörper (Coagulation Factor VIII) (C-Term)

Details for Product anti-F8 Antibody No. ABIN2788318, Anbieter: Anmelden zum Anzeigen
Antigen
  • fb61d02
  • wu:fb61d02
  • Cf-8
  • Cf8
  • FVIII
  • AHF
  • DXS1253E
  • F8B
  • F8C
  • HEMA
  • coagulation factor VIIi
  • coagulation factor VIII
  • coagulation factor VIII, procoagulant component
  • f7i
  • F8
Epitop
C-Term
22
15
15
8
6
6
6
5
5
4
3
3
2
2
2
2
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Pferd, Human, Kaninchen, Schaf
311
70
53
26
11
2
1
1
1
1
1
Wirt
Kaninchen
172
137
27
4
1
Klonalität
Polyklonal
Konjugat
Dieser Factor VIII Antikörper ist unkonjugiert
19
18
14
7
7
6
5
4
4
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
3
2
Applikation
Western Blotting (WB)
221
162
52
43
39
25
22
13
13
12
7
6
3
3
3
2
2
2
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human F8
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN976555.
Sequenz IMVTFRNQAS RPYSFYSSLI SYEEDQRQGA EPRKNFVKPN ETKTYFWKVQ
Homologie Cow: 86%, Dog: 77%, Horse: 93%, Human: 100%, Rabbit: 86%, Sheep: 86%
Produktmerkmale This is a rabbit polyclonal antibody against F8. It was validated on Western Blot.
Reinigung Affinity Purified
Andere Bezeichnung F8 (F8 Antibody Abstract)
Hintergrund This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.
Alias Symbols: AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Protein Interaction Partner: UBQLN1, GGA1, MCFD2, PHYH, LMAN1, F9, F10, VWF, F2, PROS1, PROC, HSPA5, CANX, CALR, ASGR2, LRP1,
Protein Size: 2351
Molekulargewicht 79 kDa
Gen-ID 2157
NCBI Accession NM_000132, NP_000123
UniProt P00451
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 2351 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-Coagulation Factor VIII (F8) (C-Term) antibody (ABIN2788318) Host: Rabbit
Target Name: F8
Sample Tissue: 721_B Whole Cell
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