MVP Antikörper (N-Term)
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- Target Alle MVP Antikörper anzeigen
- MVP (Major Vault Protein (MVP))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Maus, Ratte, Rind (Kuh), Kaninchen, Zebrafisch (Danio rerio), Hund, Pferd, Meerschweinchen, Schwein
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser MVP Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Sequenz
- MATEEFIIRI PPYHYIHVLD QNSNVSRVEV GPKTYIRQDN ERVLFAPMRM
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%
- Produktmerkmale
- This is a rabbit polyclonal antibody against MVP. It was validated on Western Blot using a cell lysate as a positive control.
- Aufreinigung
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human MVP
- Top Product
- Discover our top product MVP Primärantikörper
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- Applikationshinweise
- Optimal working dilutions should be determined experimentally by the investigator.
- Kommentare
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Antigen size: 893 AA
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freeze-thaw cycles.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- MVP (Major Vault Protein (MVP))
- Andere Bezeichnung
- MVP (MVP Produkte)
- Synonyme
- LRP antikoerper, VAULT1 antikoerper, 2310009M24Rik antikoerper, cb771 antikoerper, wu:fb52b05 antikoerper, wu:fc02g01 antikoerper, mvp antikoerper, MGC145641 antikoerper, Tb05.45E22.810 antikoerper, major vault protein antikoerper, major vault protein L homeolog antikoerper, putative major vault protein antikoerper, MVP antikoerper, Mvp antikoerper, mvp antikoerper, mvp.L antikoerper, Tc00.1047053510353.10 antikoerper, Tb927.5.4460 antikoerper, Tb10.70.0520 antikoerper, Tb10.70.5840 antikoerper, LMJF_05_0060 antikoerper
- Hintergrund
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MVP is required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. MVP down-regulates INFG-mediated STAT1 signaling and subsequent activation of JAK. MVP down-regulates SRC activity and signaling through MAP kinases.This gene encodes the major vault protein which is a lung resistance-related protein. Vaults are multi-subunit structures that may be involved in nucleo-cytoplasmic transport. This protein mediates drug resistance, perhaps via a transport process. It is widely distributed in normal tissues, and overexpressed in multidrug-resistant cancer cells. The protein overexpression is a potentially useful marker of clinical drug resistance. This gene produces two transcripts by using two alternative exon 2 sequences, however, the open reading frames are the same in both transcripts.
Alias Symbols: LRP, VAULT1
Protein Interaction Partner: MVP, SKIL, TRIM27, REL, PLSCR1, MEOX2, MEOX1, MDFI, KPNA3, GOLGA2, DLX2, CAMK2B, AES, TRIP6, TRAF2, TP53, TFCP2, TCF4, SUMO2, NOTCH2NL, CCDC36, TRIM42, FAM154A, PIH1D2, RAB3IP, RIMBP3, C1orf94, RHOXF2, ZMIZ2, OBFC1, RFWD2, MKL1, VAC14, BANP, FAM46C, KCTD9
Protein Size: 893 - Molekulargewicht
- 98 kDa
- Gen-ID
- 9961
- NCBI Accession
- NM_005115, NP_005106
- UniProt
- Q14764
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